Senior Scientist, Cellular Resilience

Senior Scientist, Cellular Resilience

Waltham, MA

Join AstraZeneca, a global leader in pharmaceutical innovation, where we are committed to making an impact and finding answers to challenges. We are seeking a highly motivated Senior Scientist with a broad background in implementing novel model systems in vitro and assessing in vivo studies. As a key member of our discovery team based in Waltham, MA, you will drive projects through the drug discovery process, delivering datasets that directly impact our efforts.

Accountabilities:

In this laboratory-based position, you will develop, conduct, and analyze in vitro experiments to assess the function of our candidate drugs. You will support cross-functional teams and collaborate with colleagues to ensure the timely generation and dissemination of critical program data. Your role will also involve reviewing emerging literature and internal data to help identify new potential targets and contribute to target validation activities.

Essential Skills/Experience:

• PhD in a relevant field with 0-3 years' experience with in vitro model development or MS in a relevant field with 3-5 years' experience developing novel in vitro cellular and molecular models, or BS in a relevant field with 5-8 years’ experience developing novel in vitro cellular and molecular models
• Demonstrated ability to model complex biological axes in vitro
• Demonstrated experience with genome editing techniques and epigenetics
• Strong background in cellular function assays, including cell viability analysis and flow cytometry
• Preference for experience with techniques to assess senescence (immune-specific and/or cellular)
• Ability to independently design and execute research plans for one or more programs, and to review, analyze, and interpret experimental results rapidly
• Ability to draft, execute and record protocols and experiments in a timely manner and maintain an excellent laboratory notebook
• Proven track record of success in your research and experience preparing written scientific reports and oral presentations

Desirable Skills/Experience:

• Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment

At AstraZeneca's Oncology R&D department, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are united in our vision to eliminate cancer as a cause of death. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.

About the Waltham Site

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park BioHub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world’s most vibrant research centers.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release

Ready to join us on this mission? Apply now!

If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

The annual base pay for this position ranges from $87,200 - $130,800. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.