Senior Scientist, Translational Genomics, Oncology R&D

Senior Scientist, Translational Genomics, Oncology R&D

Gaithersburg, MD

The Translational Medicine function within Oncology R&D is dedicated to ensuring effective and strategic biomarker studies for oncology project teams. As part of this function, the Global Genomics team leverages Next Generation Sequencing (NGS) and other advanced technologies to match the right patient to the right drug, supporting precision oncology approaches for the AstraZeneca Oncology pipeline. We are seeking a Senior Scientist in Translational Genomics to join our team and contribute to our mission of transforming cancer treatment.

Accountabilities:

• Perform work in a genomics lab, including planning, designing, and executing experimental work, and documenting and communicating results to appropriate partners.
• Deliver genomic information to AZ project teams and other partners using NGS and other leading-edge technologies, as well as focused informatic analyses when needed.
• Develop and maintain internal genomics lab capability with a focus on DNA/RNA purification/quantification/QC, gene enrichment, library construction through DNA sequencing (Illumina NovaSeq), and laboratory automation development.
• Involve in data analysis/QC, troubleshooting, interpretation of results, and communication back to project teams.
• Conceptualize, develop, and execute evaluations of platforms, vendors, and emerging technologies of clinical and translational utility.
• Provide technical advice and genomic/biomarker consultation to internal and external partners.
• Deliver biomarker assays and genomic/molecular profiling datasets using sample management software, a LIMS system, Jira, electronic lab notebooks, and written project reports.
• Work effectively with Translational Medicine Leads to consult on technologies, set expectations and timelines, develop project biomarker plans, and use fit-for-purpose platforms and technical approaches.
• Be accountable for high-quality biomarker data generation, validation, and results/report delivery in a timely manner.
• Lead lab-based biomarker identification focused on project needs to deliver clinically qualified biomarkers.
• Identify exploratory biomarkers relevant for drug response/resistance, patient stratification, and disease progression.
• Ensure that all nominated biomarkers are fit for purpose in the clinical environment.
• Collaborate with diagnostic, clinical, and regulatory partners to develop companion diagnostics.
• Maintain appropriate documentation for biomarker work, comply with internal and external requirements, assist in preparation of regulatory documents, and participate in external presentation of results and peer-reviewed journal publications.
• Leverage external partners for high-throughput sequencing, technology development, and other advanced genetics/genomics approaches.

Essential Skills/Experience:

• BS in relevant scientific subject area with 3 to 5 years related expereince
• Experience with Next Generation Sequencing is required
• Experience working with clinical oncology samples is required
• Experience with Beckman i7 robotic platforms including programming of new scripts and troubleshooting script errors are required
• Experience with python, bio-turing and other informatic software packages
• Strong laboratory and analytical skills
• Excellent oral and written communication skills, with clear documentation of work performed and ability to describe and understand its importance
• Excellent problem-solving skills with clear understanding of the balance of innovation, smart risks, and project delivery
• Strong organizational and planning skills
• Strong interpersonal skills and ability to multi-task project work

Desirable Skills/Experience:

• Relevant industry experience is a plus

At AstraZeneca, we are united by our vision to eliminate cancer as a cause of death. Our pioneering spirit drives us to make bold moves that transform cancer treatment and improve patient outcomes. With one of the broadest and deepest Oncology pipelines in the industry, we offer numerous opportunities to work on novel molecules at all development stages. Our collaborative environment empowers us to challenge the norm, take smart risks, and learn from failures. We are committed to applying science innovatively to shape the future of Oncology.

About Our Gaithersburg Oncology Hub

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

So, what’s next?

Join us at AstraZeneca and make a meaningful difference for patients around the world!

If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: November 20, 2024

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more-

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

The annual base pay (or hourly rate of compensation) for this position ranges from $108,757 to $161,136. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.