Multi-Omics Discovery Bioanalysis Director, Integrated Bioanalysis

Introduction to role

As a Director for Multi-omics in Discovery Bioanalysis, part of Integrated Bioanalysis in Clinical Pharmacology and Safety Sciences (CPSS), you will lead teams and devise strategies to embed the use of proteomics, metabolomics, and transcriptomics in support of safety biomarker discovery, safety screening, and wider application across the Integrated Bioanalysis function. You will lead scientists accountable for assay development, optimization, qualification, execution, and transfer of high-complexity assays using state-of-the-art instrumentation to support pre-clinical and clinical studies. This will incorporate pathway analysis, biomarker discovery, and safety risk assessment characterization. You will direct both internal delivery and oversee assay transfer and analysis to CRO partners.

You will manage a dynamic team in a matrixed environment working across the business. This role will be a key interface between our department and therapy area and excellence-function stakeholders. Working closely with our wider discovery bioanalysis organization, you will seek to maximize internal knowledge exchange and collaboration. You will be a strategic leader, able to influence at an enterprise level, and lead on the evaluation and development of innovative analytical platforms required to deliver to the portfolio based on your understanding of current and future project needs. This role will allow you to maintain our momentum in the delivery of fast proteomics, expand multi-omics in support of the acceleration of our portfolio, while also supporting interconnection of analysis for spatial biology, cellular omics, and advanced safety models. You will have the opportunity to have an immediate and lasting impact on our diverse pipeline.

Accountabilities

You will have a proven ability to develop strategy and be responsible for the successful operation of scientific activities of major significance to an organization. Based at our major R&D hub in Gaithersburg MD, US, the successful candidate will have leadership roles across laboratory groups and our vendor partners to ensure appropriate -omics methods are established. You will define our multi-omics strategy and play a key part in bringing innovative medicines to patients based on a deep understanding of multi-omics for safety and efficacy.

You will identify internal and external industry trends and anticipate future changes that impact scientific understanding in safety and efficacy. Reporting to the Head of Discovery Bioanalysis, you will be a champion for a culture of scientific curiosity and empowerment to build and support innovative research.

The right candidate will play a vital role in supporting the Integrated Bioanalysis Leadership team in making sound scientific and business decisions based on a balance of data, competitive environment, context analysis, and experience. You will ensure effective operations, resource capacity management, financial planning, and portfolio delivery.

In this role, you will need to proactively build and cultivate strong relationships across AstraZeneca and with external academic and corporate centers of excellence to help establish AstraZeneca as the partner of choice for collaborations. Leverage these partnerships to drive scientific and organizational innovation and performance beyond established approaches.

Essential Skills/Experience

• PhD in analytical chemistry, biochemistry, genomics molecular biology or related discipline with at least 10+ years of post-PhD experience or industry experience operating at this level

• Experience in managing multidisciplinary teams and overseeing and guiding experts employing multi-omic analysis platform to enable discovery and validation of metabolomic/lipidomic/proteomics biomarkers.

• Proven experience as a recognized scientific leader in an array of multi-omic techniques including development and execution of multi-omic strategies

• Technical expertise with an array of proteomics platforms including but not limited to high-resolution mass spectrometry (HRMS, ToF or Orbitrap), QqQ instruments, ligand binding assays, Olink, and other technology platforms.

• Experience with an array of multi-omic techniques including but not limited to RNA seq, cell-painting or genomics applications.

• Able to evaluate and interpret complex data, set and review bioanalytical strategies to support project decision making

• Organizational leadership experience, providing vision, direction, and fostering talent within your teams

• An understanding of the global pharmaceutical industry and the key value-creating processes within the industry.

• Proven publication and presentation record

• Exceptional verbal and written communication skills
  

Desirable Skills/Experience

• Experience in a broad range of novel therapeutic modalities including CAR-T and ADCs, immune therapeutics, as well as small molecule therapeutics

• Awareness of regulatory submission needs across geographies

• Established academic collaboration network, successful experience in achieving collaborative grant funding

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Thrive in a place where the brightest minds seamlessly come together in our inclusive environment. Here all doors are open, and every voice is heard. From working side-by-side with academia to innovating with biotech, we are forever expanding our horizons. By sharing and increasing our knowledge we are empowered to be the best we can be and accelerate progress.

Ready to make a difference? Apply now!

The annual base pay (or hourly rate of compensation) for this position ranges from $165,048.00 - $247,572.00 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.