Senior Global Medical Affairs Leader Obesity, Cardiorenal Outcomes

AstraZeneca is advancing a tailored approach to Obesity and Weight Management, uniting science, medical and commercial excellence to deliver durable outcomes, reduce cardiometabolic risk and protect organs. Our pipeline is moving with purpose and includes next generation oral and injectable therapies that prioritises tolerability, durability and quality of life. Are you ready to be at the forefront of medical innovation? As the Senior Global Medical Affairs Leader for Obesity and Cardiorenal outcomes, you'll play a pivotal role in shaping the future of obesity care. This is your chance to use your expertise to make a real impact on patients' lives. Join us in our mission to transform the patient journey, from prevention to diagnosis, and beyond.

Accountabilities

In this dynamic role, you'llbe responsible for providing medical leadership across the entire product lifecycle. You'll advise on Research & Development investment decisions, lead pre-launch scientific efforts, and accelerate evidence-based healthcare changes in the real world. Your networking and influencing skills will be key as you facilitate cross-functional collaboration and drive innovation. Are you ready to take on this challenge?

Role Summary:

Reporting to the Medical HeadofWeight Management and T2D, the Senior GMAL is a highlyexperienced Medical Affairs leaderwith proven vision and impact. Thisindividualdevelops and leadsboldmedicalstrategieswithin the obesity and cardiorenaloutcomestherapy area (specificallyheartfailure and CKD), expertlyguiding cross-functionaland cross-regional teams to deliver and exceedambitiousgoals. The Senior GMAL’sinfluence is enterprise-wide—shaping global medical agendas through Global Medical Team, Global Product Team, and Disease Area Team leadership, and deep partnership with Medical and Commercial functions in markets and regionsworldwide.

Thisroledemands a leaderwho champions innovative, disruptivethinking—identifies and shapesbreakthroughopportunities, reimagines market dynamics, and accelerateshigh-impactevidence generation and medicalchangeinitiatives. The Senior GMAL navigatesand transformshealth systems, leverages digital and advancedanalytics, drives stakeholderengagement, and ensuresAstraZeneca’s science leadsexternally and internallythroughworld-classmedicalevidence and strategic partnerships.

Expectations of a Senior GMAL include:

• Strategy & Transformation: The Senior GMAL designs and leads the implementation ofproduct and disease area strategies, as well as ambitiouspracticechangeinitiatives, at a global level. Thisrequires a deepunderstandingof healthcare system pathways, regulatory landscapes, market access, and competitivedynamics. The Senior GMAL consistently delivers innovative, disruptive solutions to shape markets, challenges status quothinking, and uses digital proficiency to identify data-driven opportunities,preparing for launch and lifecycle management.

• Medical EvidenceLeadership: Senior GMALsown the evidence generation strategy—demonstratingadvancedexperience in clinical research, interventionaltrials (Phases 2–4), and real-worldevidence (RWE) programs. Theyshapeand drivegroundbreakingclinicaltrials, registries, and RWE studies alignedwith brand, access, and practice-changingobjectives. They guide the optimisation, communication, and strategic roll-outof data acrossscientificplatforms, ensuring AstraZeneca delivers differentiatedevidencethat supports the needsofregulatory, payer, and healthcare providers. Clinical research, patient outcomesexpertise, and deepunderstandingoftreatmentprotocols underpin theirability to addressevolvingevidencerequirements.

• AdvancedScientific & Digital Engagement: The Senior GMAL blendsscientificexpertisewith strong digital acumen. Theyleverage digital healthtools, advancedanalytics, and data platforms to transform evidencecommunication, personalizestakeholderengagement, and enhance patient outcomes. Theyare the voice ofmedical—craftingcompelling narratives, driving digital dissemination ofevidence, and ensuringaccurate, impactful, and compliantscientific communications.

• Guiding and InfluencingStakeholders:Withsignificantexpertise in internal and externalengagement, the Senior GMAL builds and sustainspowerful relationships across the healthcare ecosystem—including global and regional KOLs, professionalsocieties, regulators, payers, patient organizations, digital innovators, and health systems. Theircredibility and influenceenablethem to mobilize support for medicalstrategy, evidence generation, and healthcare changeinitiatives. Theymentor andguide cross-functional teams, championingscientificleadership and strategiccollaboration.

• RegulatoryInsight & Compliance: The Senior GMAL possesseskeenregulatoryunderstanding and ensuresclinicaltrial andevidence generation initiativesaredesigned for bothscientific and regulatorysuccess. Theyanticipateevolvingregulatory and payerrequirements for evidence, ensuringhighquality, compliant data generation and communication at everystage.

Essential for the role:

• Doctorate degree with at least 5 years of experience in the pharmaceutical industry (Medical, Marketing, R&D, Market Access), or extensive experience within a health system (clinical, pharmacy, pathway design, etc.).

• Demonstrated leadership in complex, global healthcare environments, including leading franchise/TA business in key markets, driving brand performance, and managing large, diverse teams.

• Significant expertise and strategic insight into healthcare system pathways, regulatory landscapes, market-shaping, and external stakeholder engagement.

• Strong track record of internal and external network building, collaboration across geographies and matrix teams, and effective mentoring of junior colleagues or peers.

• Digital proficiency, leveraging digital health tools and data platforms to advance evidence generation and communication.

• Deep understanding of patient care pathways, evolving treatment protocols, scientific literature, and contemporary approaches to healthcare transformation.

• Proven ability to guide, influence, and align diverse stakeholders—including thought leaders, regulatory bodies, patient groups, and payer organisations.
  

Desirable for the role:

• Cardiologist with experience in heart failure

• Experience with the USA health care system

• Doctoral-level degree (MD, PhD, PharmD) in a cardiology and/or renal discipline.

• Recognisedexpertise in the relevant or related therapeutic area, often evidenced by a history of clinical practice, research leadership, or significant external engagement.

• Advanced experience designing, leading, and interpreting clinical research programs, including pivotal clinical trials (Ph2–Ph4), practice-changing RWE studies, and implementation of innovative evidence generation approaches.

• Broad experience beyond Medical Affairs; for example, prior roles in Marketing, R&D, or Market Access.

• Long-standing relationships with global KOLs, societies, regulators, digital health partners, and innovative healthcare organisations.

• Track record of launching new products or indications in multiple, diverse markets (e.g., US, China, EU), and successfully developing and executing global medical strategies.

• Location; strong preference for Boston, Massachusetts, USA

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

AstraZeneca offers an inspiring environment where scientific expertise meets business acumen. Here, you'll be equipped with the knowledge needed to keep pace with rapid complex science and the latest changes in medical practice worldwide. As scientific ambassadors, we are confident in our role within this science-led enterprise, contributing to groundbreaking innovations that improve patients' lives. With opportunities for growth and development, AstraZeneca is where your career can thrive.

Ready to make a difference? Apply now and join us on this exciting journey!