Senior Scientist

Senior Scientist

Introduction to role

We are seeking a highly motivated Senior Scientist with a track record of scientific excellence in in-vivo pharmacology to join our Oncology Small Molecules team in Waltham, MA, USA. As a Senior Scientist, you will be leading from the bench delivering in vivo pharmacology data to support our oncology small molecules' portfolio, with a focus on drugs targeting solid tumor indications including Breast, Prostate, Lung, and Colorectal cancers. 

Accountabilities

Use in vivo technical skills to support our oncology pipeline by: 

• Working hands-on in the lab developing and working with various in vivo models of cancer including subcutaneous and orthotopic xenograft models and Patient Derived Xenograft models. 

• Designing and performing in vivo pharmacology studies (tolerability, PKPD, and efficacy) and delivering comprehensive in vivo pharmacology data packages to support early and late-stage drug discovery programs. 

• Profiling of tissue samples to explore mechanisms of drug response and resistance using both traditional and novel approaches. 

• Work collaboratively across fields to develop and implement work plans and timelines. 

• Show adaptability in working with IT programs and databases to record all study data for broad access by project teams and partners. 

Essential Skills/Experience

• BS with 7+ years’ experience, MS with 5+ years’ experience or PhD with 2+ years of experience in biology, pharmacology, or related field with a minimum of 2 years “hands-on” in vivo experience.  

• Practical in vivo experience and experimental skills in the use of mouse models. 

• Ability to work both independently as well as within project teams and across subject areas such as DMPK and translational medicine. 

• Exceptional communication, listening and organizational skills. Ability to analyze, organize and present data to a diverse audience.   

• Understanding of statistical methods and quality control of data. 

• Familiarity with GraphPad Prism, Microsoft Office, and in vivo data capturing systems such as Study Log. 

Desirable Skills/Experience

• Industry experience leading strategic and technical in vivo delivery to advance drug discovery/development.  

• Experience measuring biomarkers in blood and tissue samples using techniques such as IHC, Western blot, ELISA and MSD-based platforms.  

• Experience using small animal imaging modalities such as IVIS to monitor bioluminescence.  

• Demonstrated leadership including leading from the bench

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we play an essential role in helping patients who need it the most. Our high exposure roles shape end deliverables and embrace global opportunities, working across all of AstraZeneca's Therapy Areas. With a restless need to keep improving, we are always moving forward and searching for something new. Our supportive yet challenging approach makes for an inspiring learning environment where every setback is seen as a chance to improve.

Ready to make a difference? Apply now!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.