Senior Scientist (Hematology Oncology)

Senior Scientist (Hematology Oncology)

Introduction to role:

We are seeking a highly motivated Senior Scientist in hematology oncology with a track record of scientific excellence to join our team in Waltham, MA. As a Senior Scientist, you will be leading from the bench and a member of the in vivo team focused on delivering in vivo pharmacology datasets that will have a direct impact on the drug discovery pipeline. Are you ready to make a difference in the fight against cancer?

Accountabilities:

• Use in vivo technical skills to support oncology drug discovery by:

  • Developing and working with various in vivo models of cancer including subcutaneous and disseminated cell line and patient-derived xenograft models

  • Developing, designing, and executing tolerability, PKPD, and efficacy studies to build comprehensive in vivo pharmacology data packages to support drug discovery programs

  • Profiling tissue samples to explore mechanisms of drug response using both traditional and novel approaches

• Work collaboratively across project teams and disciplines to advance projects

• Work with various software programs and databases to capture all study data

• Independently provide data analysis and interpretation

• Present in relevant meetings to project teams and stakeholders Proactively and clearly communicate within the in vivo team and the broader AZ organization

• Stay up to date with relevant scientific and technical expertise in cancer biology and pharmacology by actively reading the literature

Essential Skills/Experience:

• PhD with >2 years or MS with >5 years of research experience in biology, pharmacology, or related field

• Hands-on experience developing and working with hematological oncology in vivo models including xenografts (subcutaneous and disseminated models)

• Ability to develop and deliver clear presentations and effectively communicate key messages

• Ability to work both independently and within multidisciplinary project teams

• Strong organizational and time management skills 

• Experience using molecular and cell biology techniques such as Western blot, RT-PCR, flow cytometry, and ELISA/MSD

• Strong interpersonal skills, with evidence of delivery in a team-oriented, collaborative environment

• Familiarity with software programs include GraphPad Prism, Microsoft Office suite, and in vivo data capture systems (e.g. Study Log or similar)

Desirable Skills/Experience:

• Prior experience in biotech or pharma

• Experience delivering all aspects of PKPD, efficacy, and tolerability studies in xenograft models

• Expertise in multiple myeloma, lymphoma, and/or acute myeloid leukemia biology

• Experience with flow cytometry, including ability to design panels, profile markers in tissue using MACSQuant and/or BD cytometers, and analyze data in FlowJo

• Experience with humanized xenograft models

• Experience using small animal imaging modalities (e.g. Xenogen, ultrasound)

• Understanding of pharmacology concepts such as pharmacodynamics and pharmacokinetics

• Experience in assay development for complex systems (ex. in vivo samples, 3D cultures, co-culture etc.)

Join the team at the heart of AstraZeneca that is committed and encouraged to follow the science. Driven by our curiosity, passion, and determination we are paving the way to change the practice of medicine in Oncology. Ready to make a difference? Apply today!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.