Scientist Bioscience Immunology, Early Respiratory and Immunology

AstraZeneca is a global biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, important medicines and healthcare solutions that enrich the lives of patients. The vision of AstraZeneca Early Respiratory & Immunology (Early R&I) is centered on delivering life-changing products that advance world health and help fight and cure disease. Early R&I is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. Here, you’ll have the opportunity to make a difference in people’s lives every day.

As a part of building Immunology Bioscience team within Early R&I department, we are seeking a highly motivated scientist with a strong understanding of key biological pathways in immune-mediated diseases such as rheumatological and/or gastrointestinal diseases. This is a lab-based position. The role will be based in Waltham, MA (Boston BioHub) within AstraZeneca’s innovative laboratories where you will follow the science to help drive innovation and advance medicine to help improve patient lives.

In this role, you would be expected to demonstrate an extraordinarily high level of enthusiasm for innovative scientific research leading to the discovery and development of novel therapeutics. Ideally, you have expertise in T-, B- and highly developed immunity and/or pathogenic mechanisms involved in immune-mediated diseases. Experience in cell culture systems, cell imaging, immune assay development, flow cytometry, multiplex cytokine read-outs, qPCR and an ability to apply this experience to an understanding of the basic mechanisms of human immune-mediated disease is expected.

Main Duties and Responsibilities

This job is a lab-based research role, and you will have an opportunity to drive the direction of the work. A background in human immunology and immune-mediated diseases and translational approaches to understand basic biological mechanisms in disease is needed. Knowledge and experience of in vivo science is a bonus.

• You will focus your research on characterizing novel immunological pathways in health and disease to aid target validation and drug discovery projects
• You will be involved in the development and optimization of new biological assays
• You will implement drug discovery research experiments independently applying molecular and cellular biological techniques and analyze and interpret the data
• You will communicate the results to team members and others in the organization
• You will contribute to development of the strategies for new target identification and validation
• You will collaborate with scientists from a variety of functional teams in Waltham and with our sites in Gaithersburg, MD; Cambridge, UK and Gothenburg, Sweden.
• You will benefit from daily interaction and collaboration with highly accomplished scientists and the position offers a unique opportunity to work in a dynamic and innovative environment
• Publication of your work in high impact journals.

Requirements

• Ph.D. degree (immunology or relevant team) with 0-2 years of post-doctoral experience; Masters degree (in immunology or relevant field) with 5 years of relevant experience; B.S. degree plus 10 years relevant experience, industry experience strongly preferred
• Expertise in drug discovery projects in immunology, or a closely related field of biology, is preferred
• Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team to conduct a high-level research project.
• Strong hands-on skills in basic biochemical, immunological and molecular techniques including cell culture, quantification of mRNA (qPCR), ELISA, ELISpot, Western blot, multi-parametric flow cytometry, MSD, Luminex, etc.
• Strong written and oral communication skills and the ability to critically analyze data sets
• Proven ability to run collaborative efforts and apply external resources to find the most effective solutions to drug discovery problems
• Ability to record protocols and experiments in timely manner and maintain excellent laboratory notebook.

Why AstraZeneca?

At AstraZeneca, we adopt opportunities for change to drive significant advancements. Our mission is clear: to deliver life-changing medicines and redefine possibilities in biopharma. By combining varied perspectives, groundbreaking science, and aggressive ideas, we are transforming patient outcomes worldwide.

Where You Can Learn More

·Follow AstraZeneca on LinkedIn

·Follow AstraZeneca on Facebook

·Follow AstraZeneca on Instagram

Benefits

We offer a competitive Total Reward program, including:

·Competitive base salary, annual bonus, and long-term incentives

·Generous paid time off program

·Comprehensive benefits package

Diversity and Inclusion at AstraZeneca
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive team that represents a diverse group of backgrounds and perspectives, knowing that inclusion drives better outcomes.We welcome all qualified candidates and align with applicable laws regarding inclusivity and employment eligibility. Individuals with disabilities can request reasonable accommodations during the application or interview process, as well as for essential job functions.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.