Scientist, Process Development

We are seeking a highly motived, data-driven researcher to join our Process Development (PD) team as a Scientist. The successful candidate should have a knowledge of basic immunology principles, bioprocess development, and cGMP manufacturing. The candidate should also have experience in primary cell culture (T cells preferred), in different formats including flasks and bags. This role will support the development of a clinical manufacturing process of engineered T cells with patient-derived neo-antigen specific TCRs. The candidate will also be part of a team involved in implementing technology and participating in technology transfer to the clinical setting.  

You Will:

• Execution of process development studies to develop, optimize, scale-up and transfer cGMP manufacturing processes.  
• Perform cell culture of T cells in multiple formats including flasks, bags, and bioreactors. 
• Collaborate within the project team to interpret study results and contribute to technical discussions for subsequent study design.  
• Prepare and review experimental proposals, technical reports, SOPs and manufacturing batch records. 
• Work collaboratively within PD group and cross-functionally with other groups to meet Tech Ops organization goals. 
• Other responsibilities as assigned. 

You Have:

• MS degree in Immunology, Cell Biology, Molecular biology, Bioengineering, or relevant degrees with 2 years relevant industry experience or BS degree with 3 years relevant industry experience.  
• Experience in technical development of cell and gene therapy or biologics in early and late development setting. 
• Hands-on experience in cell and gene therapy, specifically in T cells is highly desirable. 
• Experience in Flow Cytometry is highly desired. 
• Knowledge of cGMP manufacturing and regulations and practical experience in GMP operations is highly desirable. 
• Knowledge of QbD, DOE and appropriate statistical analysis for process development 
• Ability to think critically, analytically and have demonstrated troubleshooting and problem-solving skills based on deductive reasoning. 

The annual base salary for this position ranges from $87,200 to $130,800. However, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles).

Our Benefits:

#celltherapy #LI-Onsite

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.