Senior Scientist, In Vitro Cardiovascular Biology

Do you have expertise within in vitro cardiovascular biology and enjoy working in the lab? Would you like to apply your expertise in a global company that is accelerating innovative science and turning ideas into life-changing medicines? Join us to discover future treatments for Cardiovascular, Renal, and Metabolic (CVRM) diseases!

CVRM is one of three main therapeutic research areas within AstraZeneca. Early CVRM has a patient-centric approach for discovering novel treatments for patients with cardiovascular, chronic kidney, and metabolic diseases and delivers candidate drugs into late-stage clinical development. In the Bioscience Cardiovascular department, we focus on identifying and validating new drug targets for the treatment of patients with cardiovascular disease and heart failure, as well as evaluating pharmacological aspects, such as efficacy and mechanism of action, of potential new drug candidates. The in vitro team delivers key data to projects across all phases of the drug discovery and development process, working with different modalities such as small molecules, modified mRNA, antibodies, cell therapy, antisense oligonucleotides, and peptides.

We are now recruiting a Senior Scientist with expertise in cardiovascular biology to join the Bioscience Cardiovascular in vitro team within the Cardiovascular, Renal, and Metabolism therapeutic area at AstraZeneca in Gothenburg, Sweden.

Accountabilities

As a Senior Scientist, you will play a key role in driving science and projects within the cardiovascular area forward. This is a lab-based role where you will explore novel drug targets with key in vitro data. Collaboration is critical for successful delivery of drug projects, and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. You will work with in vitro biology using cell lines, pluripotent stem cells (PSC), and primary cardiovascular cells along with molecular and functional biology techniques. You will have the opportunity to try novel techniques and ideas required for progressing existing portfolios and novel science. Responsibilities include:

• Independently design, develop and run in vitro studies and assays for target identification and validation 

• Work with molecular biology methods, imaging, and assays for functional readouts such as contractility and cardiac metabolism

• Contribute to communications of scientific findings through publications in scientific journals and at meetings

• Proactively contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared

• Engage actively in project work by collaborating with Bioscience and various functions across AstraZeneca to ensure the successful execution of key project activities

Essential Skills/Experience

• PhD or master’s degree in biology, pharmacology, cardiovascular disease or similar

• Strong experience in cell and molecular biology, biochemistry and relevant in vitro/ex vivo assays

• Minimum 2 years hands on experience in handling and manipulating relevant PSC cells and primary human and animal cardiac cell types, including cardiomyocytes

• Minimum 2 years hands on experience in in vitro work within the cardiovascular field, involving endothelial cells, cardiomyocytes, and fibroblasts in both healthy and diseased cardiovascular preclinical model systems

• Excellent English communication skills, both spoken and in writing

Desirable Skills/Experience

• Experience with cardiomyocyte biology and function in healthy and diseased systems

• Background in drug discovery and development in the pharmaceutical industry

At AstraZeneca, we are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our inclusive environment allows us to work seamlessly together, leveraging our diverse global knowledge to create the greatest impact on disease. Here you can grow your career while contributing to life-changing medicines.

Ready to make a difference? Apply now!

Welcome with your application no later than May 11th, 2025

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.