Associate Director Integrated Bioanalysis, Quantitative Mass Spectrometry

Would you like to be part of a team that is at the leading edge of bioanalysis and omics technologies? Do you aspire to work in a world-leading, innovative and cross-functional environment? Are you looking to join a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

We are seeking for a motivated and passionate individual to join us as an Associate Director, EUDiscoveryBioanalysis, Quantitative Mass Spectrometry, in ourIntegrated Bioanalysis (IBA) organization within Clinical Pharmacology and safety sciences (CPSS). Leading a European-based team by example, you will support ADC and biopharmaceuticaldrugdiscovery and development, Multi-omic studies as well as biomarker assessments for critical projects within the AstraZeneca portfolio employing mass spectrometry-based approaches.

You will work at the forefront ofbioanalytical sciences and play a key role in the development and progression of new medicines to the market. We are looking for an enthusiastic and innovative team player with experience of line management  anddetailed knowledge of Bioanalysis  LC-MS workflows and demonstrated hands-on experience.You will need to use your experience and consistent track record to design, develop and deliver robust bioanalytical strategies and associated bioanalytical methods; you will need toensure that assays are shown to be fit-for-intended purpose and provide data that will allow project teams to make informed decisions with confidence.As a Subject Matter Expert, you will be responsible for enhancing the iBA reputation for scientific excellence by presenting at internal and external meetings, and publishing manuscripts. You will be expected to represent the department on multidiscipline, cross functional, drug development teams and work alongside colleagues & stakeholders across iBA and CPSS functions and partner organisations. 

The position will be based at our vibrant strategic R&D site in Gothenburg, Sweden.

What you will do

As an Associate Director, IntegratedBioanalysis, Quantitative Mass Spectrometryin IBA at AstraZeneca, your main accountabilities will be to:

• Lead a team of bioanalytical and mass spectrometry experts, based in the UK and Sweden, in non-GXP bioanalysis of large molecules

• Developnovel quantitativemass spectrometry workflows combining digestion-based or intactmolecule analysis to address sophisticated bioanalytical challenges related to drug discovery and developmentfor ADC, oligonucleotide and other drug modalities in a variety of biological matrices.

• Elaborate, validate/qualify state-of-the-art mass spectrometry assays in support of pharmacokinetic, toxicokinetic, pharmacodynamic, mechanistic, safety, prognostic and diagnostic biomarkers 

• Lead internal/external collaborative projects working together with safety scientist, pharmacologists, toxicologists, imaging scientists, pathologists, data scientists and translational science experts across global AstraZeneca teams

• Support effective project planning and project management, from sample arrival through to assisting with reports to collaborators.

• Operate, maintain and troubleshoot a variety of recent instruments

• Serve as functional representative/expert on multidisciplinary project teams 

• Adhere to established Standard Operating Procedures, industry practice and regulatory guidance as appropriate

• Contribute to validation/qualification protocols and reports, bioanalytical reports, clinical study reports, as appropriate

Requirements:

• PhD in Analytical Chemistry, Biochemistry or related field with a strong expertise in mass spectrometry for bioanalysis and antibody drug conjugates. 

• Innovative and influential bioanalytical leader capable of defining, leading and implementing robust bioanalytical strategies, risk mitigations and solutions to challenges in support of diverse project teams.

• In depth knowledge of bioA/biomarker concepts such of “context of use or fit for purpose assay validation/qualification.

• 5+ years of relevant industry/biotech experience in mass spectrometry-based bioanalysis.

• Experience of leading teams, with proven ability to coach, mentor and manage people to successfully deliver to projects.

• Excellent skills in study design, implementation of challenging and innovative LC-MS assays and data interpretation in the field of biomolecule characterization and/or multi-omics.

• Hands-on experience in the operation of high resolution (qTOF, IMS-TOF, Orbitrap) and QqQ instruments and demonstratedexperience with various acquisition modes (DDA, DIA, PRM, MRM, etc)

• Proven track record of sample preparation and data acquisition method development and optimization.

• Strong record of productivity and scientific publications.

• Excellent organizational, documentation and technical writing skills.

• Excellent command of English (written and oral)

• Strong communication and interpersonal skills.

Desirable:

• Experience with a broad array of multiomics techniques including, but not limited to, proteomics, metabolomics, lipidomic, RNAseq, cell- painting or genomics applications.

• Background in bioinformatics/statistical analysis.

• Familiarity with biomarker discovery and validation and with drug metabolite identification and profiling studies. 

• Applied knowledge of bioanalytical techniques that would strengthen the departmentsbioA toolbox e.g., Flow Cytometry, HPLC-MS/MS, high sensitivity immunoassay platforms, qRT-PCR, dd-PCR.

• Contributed to regulatory submission documentation such as INDs, CTAs, IBs, ISI and/or NDAs/BLAs and experience in regulatory authority responses across multiple geographies.

• Proven experience of operational streamlining and use of innovation tools, such as AI, within the workplace.

Why AstraZeneca?