Senior Scientist, Translational Proteomics, Global Mass Spectrometry

Senior Scientist, Translational Proteomics, Mass Spectrometry

Introduction to role

Do you have a passion for Translational Proteomics and Mass Spectrometry? We are looking for a bold scientist to impact the clinical development of oncology drugs with innovative biomarkers and turn novel ideas into life-changing medicines! Join us and make a difference in the world of cancer treatment.

Accountabilities

AstraZeneca is seeking a motivated scientist to join the Translational Proteomics team within our Cancer Biomarker Development (CBD) group located in Gaithersburg, MD. The scientist will develop and apply mass spectrometry-based proteomics workflows for biomarker quantification to accelerate the development of AZ’s oncology medicines. This position requires expertise in quantitative mass spectrometry for clinical samples and strong communication skills to collaborate across multidisciplinary teams.

• Develop and validate innovative DIA-based mass spectrometry proteomics for biomarker studies.

• Process clinical samples (e.g., FFPE tissue, frozen tissue, plasma) for translational and clinical studies.

• Operate high-resolution instruments (TimsTOF Ultra2, Exploris 480) and ensure high-quality data.

• Analyze R&D and clinical data, summarize results, and present key results internally and externally.

• Collaborate with translational biologists and bioinformatics teams to develop protein biomarkers.

Essential Skills/Experience

• Ph.D. in bioanalytical chemistry or related field with 0-4 years post-doctoral experience in quantitative mass spectrometry-based proteomics.

• Extensive hands-on experience with high-resolution mass spectrometry instrumentation for method development, data acquisition, troubleshooting, and quality control.

• Experience with biological sample preparation (tissue, plasma) for quantitative LC-MS applications.

• Expertise in untargeted proteomics data analysis (Skyline, Spectronaut, MaxQuant, DIA-NN) and downstream interpretation (differential expression, pathway analysis).

• Proficient programming skills (R, Python) and statistics for advanced data analysis and visualization.

• Demonstrated ability to work independently and collaboratively with strong communication skills.

Desirable Skills/Experience

• Experience with sample preparation using liquid handling robotics.

• Experience working in regulated environments (GCP/GLP).

AstraZeneca is a place built on courage, curiosity, and collaboration. We make bold decisions driven by patient outcomes. Empowered to lead at every level, you will be free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team. Work with experts who share a common goal: to accelerate the potential of medicines and the science of tomorrow.

Ready to make a meaningful impact? Apply now!

The annual base pay (or hourly rate of compensation) for this position ranges from $112,164 to $168,246. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.