Senior Scientist – Mass Spec & Analytics

Senior Scientist – Mass Spec & Analytics

Introduction to role

Are you ready to make a difference in the world of medicine? Join AstraZeneca's Biologics Engineering team, where innovation meets impact. We are seeking a highly skilled Senior Scientist to join our Mass Spec & Analytics Group within the Protein Analytics & Developability team. In this pivotal role, you will drive advancements in high throughput protein analysis and peptide mapping, supporting our pipeline projects and enhancing our technology platforms. Collaborate with a multidisciplinary team and contribute to life-changing medicines!

Accountabilities

• Develop and utilize advanced analytical tools, focusing on mass spectrometry and chromatography-based techniques, to characterize discovery-stage biotherapeutics, facilitating critical decision-making.

• Design and execute peptide mapping assays for protein characterization to support the developability assessment of pipeline projects.

• Conduct analytical methods to deeply characterize the biophysical and biochemical properties of discovery-stage biologics.

• Perform and optimize high-throughput (HT) intact protein analysis for discovery-stage biologics, including antibodies, multispecifics, and various protein reagents.

• Collaborate with the Protein Analytics and Developability team to refine HT assay workflows, ensuring accuracy and reliability in data collection and interpretation.

• Analyze and interpret complex datasets, providing insights to drive decision-making in pipeline projects.

• Stay at the forefront of technological advancements in mass spectrometry and other analytical technologies, integrating innovative solutions to enhance current workflows.

• Participate in cross-functional project teams, contributing technical expertise to inform project strategies and directions.

• Draft technical reports and contribute to scientific publications, patents, and regulatory submissions as necessary.

• Mentor junior scientists in experimental design and data analysis to foster a collaborative and productive research environment.

Essential Skills/Experience

• Ph.D. in Biochemistry, Chemistry, or Bio/Chemical Engineering with at least 1 year of relevant hands-on experience, or a Master’s degree with 4+ years of relevant hands-on experience.

• Proven expertise in LC-MS (ThermoFisher Orbitrap, Agilent QTOF) and software platforms, including BioPharma Finder, PEAKS, and Protein Metrics Suite, for intact mass deconvolution, peptide mapping analysis, post-translational modifications (PTMs), characterization of charge variants, and disulfide mapping.

• Hands-on experience with a wide variety of analytical methods for protein characterization, including but not limited to LC-MS, HIC, SEC, cIEF, IEX, CE-SDS, DLS, DSC, and DSF.

• Experience in assay troubleshooting and optimization, with a strong understanding of assay development and execution.

• Proficiency in data analysis and statistical methods for interpreting complex biological data.

• Hands-on experience with other protein analytical and biophysical techniques and instrumentation is advantageous.

• Strong collaborative skills and ability to work effectively within multidisciplinary teams.

• Excellent communication and presentation skills to convey technical information clearly and succinctly.

At AstraZeneca, we are committed to making a meaningful impact on patients' lives. Our dynamic environment encourages innovation and collaboration across all therapy areas. We embrace challenges as opportunities for growth and are dedicated to pushing boundaries in medicine development. With a focus on continuous improvement, we empower our teams to explore new ideas and make bold decisions that can change the course of healthcare. Here, you will find countless learning opportunities and the chance to contribute to groundbreaking solutions that benefit society globally.

Ready to take on this exciting challenge? Apply now to join our team at AstraZeneca!

The annual base pay (or hourly rate of compensation) for this position ranges from $108,473 to $162,710. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

10-Jul-2025

Closing Date

17-Jul-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.