Senior Scientist COPD/IPF

Whatyou willdo:

This job is a lab-based research role, and you will have a significant opportunity to influence the direction of the work. The work will bepredominantly withhuman in vitro systems, working with primary and disease tissue-derived cells. Ideally, you have strongexpertisewith primary cell culture (human lung stromal cells and macrophages) and in vitro techniques assays such as Westerns, ELISAs, PCR. Experience in IHC, Ventana is a plus.

You will focus your contributions to a team focused on characterizing novel biology pathways pertinent to chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) to aid target validation and drug projects 

Examples of accountability

You will focus your contributions to a team focused on characterizing novel biology pathways pertinent to chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) to aid target validation and drug projects 

In a team setting, you will contribute by applying molecular and cellular biology techniques, and to interpret and communicate results to team members 

You will support new target identification and validation You will collaborate with scientists from a variety of functional teams in Gaithersburg and with our sites in Cambridge, UK, and Gothenburg, Sweden

Essentials for the role:

• AMaster's or Bachelor’sdegree in biology or related fields 

• Expert in IHC, Ventana and respiratory biology (COPD, IPF)

• Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team to contribute to research projects 

•  Demonstrated ability to design and conduct laboratory projects/experiments, develop methods, generate and interpret scientific data; competent in trouble shooting and critiquing data

Additionally, theoptimalcandidate willpossess:

• Strong hands-on skills in basic biochemical and molecular techniques including cell culture, quantification of mRNA (qPCR) and protein expression; ELISA, as well as assay development  

• Expertisein primary human cell culture, especially Air-Liquid-interface epithelial cell cultures, primary lung fibroblasts, immune cells, macrophages

• Strong written and oral communication skills and the ability to critically analyze datasets 

• The ability to work as part of a team and collaborate with colleagues across a variety ofdiscipline

Desirable for the role:

• Experience inVentana,MSD 

• Experience with PowerPoint, Excel, GraphPad Prism

• Drug discovery experience is a plus