Translational Science Lead

Job Title: Translational Science Lead

Introduction to role

Are you ready to bridge the gap between bench science and bedside clinical practice? At AstraZeneca, our Translational Science Lead (TSL) plays a pivotal role in our Precision Medicine groups within the Translational Science and Experimental Medicine (TSEM) department. We are committed to understanding disease mechanisms at the molecular level, identifying the most relevant targets, and driving patient stratification in Respiratory & Immunology (R&I) diseases. As a TSL, you will lead the development of translational science strategies, ensuring target engagement and human target validation, and delivering evidence to confirm proof-of-mechanism in clinical trials. This role spans from conceptual target ideas through early drug development and all clinical phases, including Phase 3 and life cycle management opportunities. Join us in our mission to bring precision medicine propositions to the clinic!

Accountabilities

• Develop and integrate translational science strategies for R&I projects and clinical studies, focusing on human target validation, target engagement, and precision medicine.
• Build mechanistic understanding of targets and diseases through innovative experimental methods and technologies.
• Establish translational evidence packages for new targets using public and proprietary biobanks.
• Identify and enable PoM biomarkers to demonstrate target engagement at First Time In Human (FTIH).
• Deliver precision medicine strategies to identify patients most likely to benefit from our medicines.
• Represent TSEM’s translational and precision medicine strategy in investment decisions and governance interactions.
• Integrate translational and precision medicine strategy into key clinical documents.
• Interpret biomarker data from clinical studies to enhance patient outcomes.
• Contribute to regulatory and health authority responses, authoring submission document sections related to Mode of Action, PK/PD, and precision medicine.
• Prepare and review scientific publications to support publication and marketing strategies.

Education/Experience

• PhD or MD equivalent with a strong experimental drive and background in relevant scientific field
• Post-doc experience or otherwise relevant scientific research experience
• Experience in an academic and/or industry setting
• Strong publication record

Required Skills/Experience

• Proven ability to deliver in precision medicine and human target validation applied to drug discovery
• Excellent understanding of Immunology and/or Respiratory therapy areas and disease biology
• Experience with patient stratification, precision medicine, and biomarker invention
• Familiarity with target engagement biomarkers and PoM biomarker implementation
• Broad understanding of relevant technologies and methodologies with excellent scientific laboratory skills
• Strong skills in hypothesis forming, testing, and drawing conclusions from experimental data
• Demonstrated leadership skills and ability to be a self-starter
• Strong team working skills with a proven track record of collaborative work
• Excellent written, oral, presentation, and interpersonal skills

At AstraZeneca, we are driven by our passion for science and our commitment to making a difference. We are fusing data and technology with the latest scientific innovations to achieve breakthroughs that can redefine what's possible in healthcare. Our inclusive environment encourages collaboration across academia, biotechs, and industry, allowing us to create the greatest impact on disease. With opportunities for continuous learning and career development, we empower our team members to explore without limits.

If you are ready to make a significant impact on patients' lives through innovative science, apply now to join our team at AstraZeneca!

So, what’s next?

Please complete your application before the below closing date (27th May 2025)

We look forward to hearing from you. 

Where can I find out more?

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Join us today and be a part of the change!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.