Senior Scientist, Immuno-oncology Research

Job Title: Senior Scientist, Immuno-oncology Research

Introduction to role:

At AstraZeneca, we turn ideas into life-changing medicines. Working here means being entrepreneurial, thinking big, and collaborating to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.

Are you ready to work on one of the most exciting pipelines in the Oncology industry?

AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and ultimately eliminate cancer as a cause of death.

We are seeking a highly motivated in vivo Senior Scientist with deep scientific and technical expertise in immuno-oncology mouse models and a track record of scientific excellence to join our Discovery Immune Cell Engagement team in Cambridge, UK. As a Senior Scientist, you will be a key member of a team focused on supporting immuno-oncology projects through the drug discovery process. You will bring your theoretical and practical expertise in immunology and in vivo modelling to design studies and deliver datasets that will have a direct impact on immuno-oncology research projects.

Accountabilities:

Working in this laboratory-based position, you will develop, design, conduct, and analyze in vivo and ex vivo experiments to assess the function of our candidate drugs and help us to dissect the mechanism of action of novel therapeutics targeting the immune system for cancer therapy. You will carry out in-depth ex vivo analysis of samples from tumor studies (e.g., high-dimensional flow cytometry, ELISA, RNAseq, etc.), to understand the effect of test substances on immune function in complex preclinical models (including humanized mouse models).

In-depth technical expertise in immuno-oncology preclinical modeling and analysis of immune function is essential for this role. As a highly organized and self-motivated individual with a strong lab/practical background, you will drive innovation in preclinical modeling and actively keep up-to-date with new technological developments and have a genuine passion for this field of research.

Essential Skills/Experience:

• PhD or equivalent experience in immunology/immuno-oncology/cancer biology

• Hands-on experience with animal handling and procedures including dissection and tissue collection and running in vivo models, particularly oncology models

• Experience in a range of technical skills such as tissue culture techniques for cell-based immunoassays, experience working with immune cells, multiparameter flow cytometry, and ELISA workflows

• Expertise in design, statistical analysis, and interpretation of in vivo studies

• Depth of understanding and strong enthusiasm for immunology and immuno-oncology

• Experience preparing written scientific reports (e.g., manuscripts) and oral presentations (e.g., slides, posters)

• Strong interpersonal, influencing, negotiating, and collaboration skills together with evidence of having used these skills to support problem-solving and in delivering projects in a collaborative environment

• Willingness to work flexibly; including occasional evenings as necessary

Desirable Skills/Experience:

• Experience using preclinical mouse models of tumor immunology

• Experience working with humanized mouse models

• Home Office Licence (Modules 1-4) or equivalent qualification for animal work and experience working under Home Office Regulations (as a Personal Licence Holder)

• Experience in visualizing/quantifying high content multi-parameter flow cytometry data /transcriptomic datasets

• Prior experience with spectral flow cytometry

• Knowledge of the drug discovery process

At AstraZeneca, we follow the science and pioneer new frontiers. Join our team dedicated to Oncology with an ambition to eliminate cancer as a cause of death. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Fusing cutting-edge science with the latest technology to achieve breakthroughs. 

Ready to make a difference? Apply now!

So, what’s next?

Please complete your application before the below closing date (10th March 2025)

We look forward to hearing from you. 

Where can I find out more?

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Join us today and be a part of the change!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.