Senior Research Scientist – Protein Engineering and Novel Modalities

Job Title: Senior Research Scientist – Protein Engineering and Novel Modalities

Locations: Cambridge, UK

Salary: Competitive + Excellent Employee Benefits!

Applications Deadline: March 16

Introduction to role:

Are you ready to take a crucial inter-disciplinary approach to deliver life-changing medicines? We are seeking a highly motivated Senior Research Scientist to help support our Respiratory and Immunology discovery pipeline. The role will involve developing and implementing our next-generation modalities in their application to pre-clinical programs.

The Biologics Engineering (BE) team leads the generation of biologic drug candidates and the development of new technologies with the potential to create first- or best-in-class therapeutics. It is our mission to be innovative, courageous, and collaborative in discovering life-changing medicines. We live in an era of explosive growth in science and technology. By harnessing this wealth of new knowledge and technological innovation, we can boldly embrace and conquer new challenges in drug discovery.

Accountabilities:

As a Senior Research Scientist, you will bring your expertise in multivalent molecular design to the table. Your experience in the antibody drug design will be crucial in creating and characterising the next generation of biologics, with a focus on multi-specific molecules and inhaled biologics. You will execute experiments efficiently, analyse, interpret, and present data and ideas to a wider audience.

Essential Skills/Experience:

• Ph.D level scientist, or Batchelor’s degree with significant experience in an industry setting.

• Deep understanding of antibody structure-function relationships.

• Strong hands-on experience in molecular biology methods and technologies e.g., PCR, RT-PCR, cloning (ligation-dependent and independent methods), site-directed mutagenesis, Sanger sequencing/analysis.

• Experience in protein design, production and characterisation of antibodies, or antibody-like scaffolds using common expression systems (e.g. mammalian) and purification methods (e.g. Akta systems), and the ability to profile constructs (e.g. SPR; biochemical assays).

• Ability to work independently, to optimize protocols, troubleshoot, interpret experimental results/data and maintain accurate, high quality and up-to-date experimental records.

• Strong communication skills in a team environment and an ability to quickly learn and adopt new technologies.

Desirable Skills/Experience:

• Background in drug discovery and development in the pharmaceutical industry or academia.

• Strong publication record, as evidenced by patents and/or publications.

• Hands on experience in bioconjugation methods.

• Hands on experience in inhaled biologics.

• Experience of using lab automation and/or High/Throughput protein expression and purification.

Why AstraZeneca?

At AstraZeneca, we stand at the forefront of scientific innovation, passionately merging cutting-edge technology with groundbreaking research to redefine the boundaries of drug discovery and personalized healthcare. We cultivate an environment where curiosity and courage propel us to tackle the biology of complex diseases without fear of failure, driving bold decisions and ambitious breakthroughs.

Our team thrives in a supportive atmosphere, equipped with state-of-the-art resources that empower professionals to celebrate both their triumphs and setbacks. With us, you will not only impact the future of medicine but also enjoy competitive compensation, benefits, and robust career development opportunities. Join us on this exciting journey to make a meaningful impact in the world.

So, what’s next?

• Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

• Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.

• We encourage you to apply online before midnight on March 16.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.