Why choose AstraZeneca Spain?
AstraZeneca Spain is a rising force in our global business. With headquarters in Madrid and our global hub in Barcelona, we’ve become an important international centre of excellence in the fight against critical disease. Boasting vibrant universities and business schools, the Barcelona ecosystem is a place where scientists can thrive. We attract a diverse workforce from across the globe, shining a beacon for innovation in a country that’s committed to clinical development.
We invite you to bring your talents to Barcelona where our respiratory medicine R&D and Global Marketing centre offers opportunities in R&D, IT, Commercial and HR. Or join us in Madrid and shape our growth in our BUs (Respiratory, Oncology & CVRM ), and a range of Corporate functions. Additionally, you can find sales roles throughout the country. Together, we’re contributing to a world-leading pipeline of therapeutics and delivering life-changing medicines to patients.
Who do we look for?
Calling all tech innovators, ownership takers, challenge seekers and proactive collaborators. At AstraZeneca Spain, breakthroughs born in the lab become transformative medicine for the world's most complex diseases. Alongside technical expertise, colleagues have the resilience, energy and collaborative mindset to change lanes, work with different teams and start projects from scratch.
Here, diverse minds and bold disruptors can meaningfully impact the future of healthcare using cutting-edge technology. Whether you join us in Madrid or Barcelona, you can make a tangible impact within a global biopharmaceutical company that invests in your future. Join a talented global team that's powering AstraZeneca to better serve patients every day.
Success Profile
Ready to make an impact in your career? If you're passionate, growth-orientated and a true team player, we'll help you succeed. Here are some of the skills and capabilities we look for.
Diverse collaborators
This is a speak-up culture that values collaboration. You’ll proactively bring your unique perspectives, experiences and skills to the table and seek the same from others. With our international team composition and the need for fast-paced collaboration, you’ll always be building new connections with colleagues.
Cutting-edge innovators
When you join us, you’ll be part of a team that embraces digital technology and data to transform the way we work and the work we do. Every day, you’ll help make history, empowered to ignite your creativity and build something enduring.
Resilient trailblazers
Here, the answers aren’t always available. So, you’ll need to bring a fearless, self-starter mindset to navigate uncharted territories. You’ll harness your ceaseless energy to discover and make the necessary connections with colleagues to shape the future and achieve maximum impact.
Agile movers
Seize ownership and excel with autonomy to enjoy the constant rush of ground-breaking discovery. Your ability to anticipate sudden shifts and adapt swiftly will prove critical as you make your mark in an environment that rewards initiative and resilience.
Responsibilities
Director is accountable for setting CPQP objectives/plans to ensure delivery of business objectives. Responsible for establishing, directing and providing strategic, tactical and scientific leadership to the area. May possess special knowledge in functional area(s) and seen as a source of reference on specific topics. Is expected to serve as CPQP lead to drug development programs and be accountable for all CPQP-related matters, across all phases of drug development. Contributes to business development and will influence strategic direction.
Introduction to role
The Director, CPQP position resides within Alexion’s Clinical Pharmacology and Safety Sciences (CPSS) organization. As the CPQP lead, you will provide subject matter expertise and program-level functional and operational leadership to the global development team(s) on all issues related to clinical pharmacology and quantitative pharmacology. You will develop and lead assorted clinical pharmacology (CP) and quantitative pharmacology (QP) plans and model-informed drug development strategies as appropriate (population analyses, exposure-response, PBPK, etc). Representing the CPQP function on drug development teams, leading CPQP sub-teams, and owning strategy and delivery on posology for early and late-stage clinical trials, you will collaborate with clinicians, clinical operations, bioanalytical, biomarker, pharmacovigilance, regulatory, and CMC groups. This role requires strong communication and interpersonal skills and involves leading a team of scientists to develop and handle clinical pharmacology plans and exposure response analyses for compounds from early-stage (pre-clinical to first-in-human up to proof-of-concept) to late-stage clinical development (proof-of-concept up to post-marketing approval).
Accountabilities
• Represent CPQP function at the Global Project Team and lead CPSS sub-team.
• Lead the development of the clinical pharmacology (PK, PD, biomarkers, Bioanalytical) sections of early and late-stage clinical protocols, Clin Pharm development plans, and assorted QP analysis plans.
• Prepare the pre-IND, IND, IB, and IMPD documents.
• Design early phase clinical trials (FIH to POC) and support project goals.
• Recommend the starting dose in FIH trials based on allometric scaling or physiologically based modeling or QSP modeling.
• Conduct assessments of relevant exposure vs. response data for supporting dose selection during and post POC; Contribute to the design of late-stage clinical trials (POC-BLA/NDA) and support project goals.
• Prepare the PK/PD reports/sections of clinical study reports.
• Provide clinical pharmacology input and collaborate across all areas of drug development.
• Primary owner of delivering pharmacokinetic/pharmacodynamic data analyses using standard industry data analysis software.
• Deliver clinical pharmacology components of clinical study protocols and clinical study reports.
Essential Skills/Experience
• Doctoral degree (PhD or Equivalent training by experience) in clinical pharmacology, pharmacology/cell biology/immunology, or relevant field.
• At least 10 years of pertinent post-doctoral experience in supporting pharmacokinetics, pharmacodynamics, and other CP and QP components of early- and late-stage clinical trials.
• Knowledge of data analysis methodologies for implementation in analyzing early- and late-stage clinical phase data, including applying model-informed drug development (MIDD) strategies to inform program decision-making.
• Knowledge of general regulatory process and experience in contributing to IND, EOP1, EOP2, and pre-BLA/NDA meetings with the FDA and EMA.
• Excellent written and oral communication skills including good presentation skills.
• Strong discernment; including knowledge of the multidisciplinary functions involved in a company’s drug development process, e.g., clinical operations, research, biostatistics, clinical pharmacology, regulatory, commercial operations, etc., and can proactively integrate multiple perspectives into the clinical development process for the best end-results!
Desirable Skills/Experience
• Prior multi-disciplinary team-facing experience in a CPQP
• Genetic Medicine Development
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and bold world.
At Alexion, AstraZeneca Rare Disease, we are driven by our commitment to serve patients. Our work is led by their lived experiences, driving what we do and how we do it. We know our patients by name; we meet their families and their careers. Our close connection with patients inspires us to begin the toughest challenges for them. Join us to grow and innovate in a rapidly expanding portfolio within a supportive culture that values integrity, inclusiveness, and dedication.
Ready to make a difference? Apply now!
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
Reasons to Join
Thomas Mathisen
There are many things I enjoy when working at AstraZeneca, mainly the Speak up culture, the great colleagues that are in my teams, the great products that AstraZeneca provides to our patients and the challenging conversations I have around our medicines.
Christine Recchio
Working at AstraZeneca has impacted my life in such a positive way. I now have an improved work-life balance through creating my own schedule and time management, I feel a balance that I didn’t have before.
Stephanie Ling
There are a lot of reasons why I enjoy working in AstraZeneca, my colleagues being one of them. My team members and the managers have provided a great deal of guidance in helping me to be more confident in my daily work.
What we offer
We're driven by our shared values of serving people, society and the planet. Our people make this possible, which is why we prioritise diversity, inclusivity, balance and sustainability. Discover what a career at AstraZeneca could mean for you.
An award-winning company
We're passionate about being a great place to work, and 84% of our employees would recommend us as an employer. We've been recognised as a Top Employer in Spain, an EFR Family Responsible Business, and we achieved third place in Forbes Spain's Top 50 Best Places to Work list.
Inclusive environment
Diversity and inclusion are embedded in everything we do, and our different views, experiences and strengths enrich our culture. There's no salary gap at AstraZeneca, and the number of female employees has increased by four per cent over the last three years. We've also made all positions fully accessible.
Work-life balance
Your wellbeing means a lot to us, and we're here to support you through all of life's ups and downs. That's why we offer an unpaid leave policy, annual leave, reduced-hours timetables and a host of benefits, including a retirement plan, long service award, and health and travel insurance.
Sustainability initiatives
We're committed to harnessing the power of science to become a more sustainable business. We've reduced our carbon footprint by over 9,000 kg of CO2 over the last two years, and we lead the European GoGreen Project, which aims to introduce environmentally friendly options in our fleet of corporate vehicles.
We’ll keep you up to date
