Clinical Pharmacometrician, Clinical Pharmacology and Quantitative Pharmacology

Introduction to role:

Join our dedicated Biopharmaceuticals R&D team as a Clinical Pharmacometrician. This scientific role involves responsibility for pharmacometrics activities across all clinical development phases. You will be integrating and analysing data to support decision making at both study and project levels. This is an opportunity to apply your expertise in pharmacometrics techniques and business domain knowledge to generate scientific insights and influence our pipeline.

Accountabilities:

As a Clinical Pharmacometrician, you will be accountable for expert data integration, analysis, interpretation, and reporting of M&S results at the study level. You will execute state-of-the-art M&S techniques with direct value for the project and use M&S to influence study designs and go/no go decisions. You will also contribute to regulatory documents and interactions, present M&S results in internal and external forums, and participate in peer review of ongoing activities, reports, and presentations.

Essential Skills/Experience:

- Demonstrated expertise in pharmacometrics, including PK, PK/PD and/or statistics

- Strong quantitative skills (e.g. experience in population modelling, statistics, systems and translational pharmacology modelling)

- Expert knowledge of pharmacokinetics and Model-Informed Drug Development (MIDD)

- Demonstrated broad translational and clinical development expertise and experience exemplified by 3-6 Years of drug development experience, with emphasis on Clinical Pharmacometrics

- Demonstrated ability to identify, develop and execute Pharmacometrics activities at a project level

- Good English language oral and written communication skills

- Good knowledge of global regulatory, compliance, processes, standards and issues specific to clinical pharmacology

- PhD degree preferred or equivalent (M.Sc./Pharm.D.) with relevant experience required

- Relevant regulatory experience (written)

- Training and experience with PK, pharmacometric and statistical software (R, nonmem, monolix, nlmixr, stan, winbugs, phoenix/nlme)

Desirable Skills/Experience:

- Scientific publishing in the field on pharmacometrics

- Early or late phase clinical development experience/awareness

- Knowledge in pharmacology, drug targets and core disease areas

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we are driven by our desire to understand and reveal new insights. We are committed to making a difference by fusing data and technology with the latest scientific innovations to achieve breakthroughs. We celebrate our successes and failures along the way as we push the boundaries of science to deliver life-changing medicines. We work seamlessly as one, uniting the best from academia, biotechs and the industry. We are investing to enhance our understanding of disease and pioneering new approaches to better predict clinical success. If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be.