Sr. Scientist – Gene Delivery

We are seeking an innovativeSenior Scientistto join theCellular Resilienceteam and contribute to groundbreaking early-discovery research at the intersection ofgene deliveryandcell therapy. The successful candidate will leverage their expertise ingene delivery,vector design, and/orcellular engineeringto develop the next generation of cellular therapies.

Key Responsibilities

• Vector design and production: Conceive, performin silicodesign of, and experimentally produce genetic vectors.

• Cell engineering: Engineer cell lines and primary cells using viral and non-viral techniques.

• Assay development: Developin vitrocellular assays with an emphasis on high-throughput readouts such as multicolores flow cytometry and imaging.

• Data analysis and communication: Analyze and interpret complex experimental data and present findings to internal and external stakeholders.

• Cross-functional collaboration: Collaborate with cross-functional teams to advance research projects from concept through preclinical development.

Qualifications

• Education and experience: PhD with0-5 yearsof post-graduate experience in a relevant field, including but not limited tobioengineering,chemical engineering,biomedical engineering,molecular biology,synthetic biology,biochemistry, andimmunology.

• Scientific impact: Demonstrated ability to advance their field through high-impact scientific publications and/or patents.

• Independent scientific leadership: Ability to independently conceive, design, execute, and draw conclusions for projects with minimal guidance.

• Working style: Proactive, highly self-motivated, and able to thrive in a workplace where goals may shift.

Preferred Qualifications

• Gene delivery expertise: Experience in state-of-the-art gene delivery modalities, including but not limited toVLPs,LNPs,exosomes,AAV,lentivirus, andelectroporation.

• Protein engineering experience: Experience in protein engineering, with an emphasis on designing protein/DNA constructs and integrating constructs into appropriate vectors.

About the Waltham Site

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park BioHub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world’s most vibrant research centers.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly designed, activity-based workspaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release

Ready to join us on this mission? Apply now!

If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long-term incentive. We have a generous paid time off program and a comprehensive benefits package.

The annual base pay for this position ranges from $116,284.00 - $174,426.00. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.