Senior Research Scientist, Chemical Biology & Proteomics

We areseekingahighly motivatedandtalentedscientist to join ourChemicalBiology & Proteomics(CBP)teamat AstraZeneca in Waltham, MA.As aSenior Research Scientist, youwill be an integral member of a team generating pre-clinical pharmacology data to understandefficacyand selectivityof therapeutic agents. You will have the opportunity to work witha team ofcross-functionalscientists and support the development of new and successful therapiesfor patients.Ifyou’reinspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

KeyResponsibilities

• Develop andemploychemicaltoolsandproteomicstechnologies toprovideimpactfulmechanisticinsightsfordrug discoveryprojectsacrosstherapeutic areas

• Develop mass spectrometry-based methodsto conductcovalentscreens

• Design and execute experimental plans to understandtarget engagementandselectivityprofilesof therapeutic agents,understand drug-induced proteomedynamicsand investigatepost-translational modifications (PTM)

• Represent CBP team, and communicate withprojectdiscipline leads, andcontribute togeneration ofmechanistic hypothesisthroughinterpretation of sophisticated proteomics data

• Maintainand troubleshootLC-MSsystem

Essential Requirements

• PhD with2+ yearsof post-doctoral/industrialexperience

• Knowledge and hands-on experience with sample preparation and method development on quantitative mass spectrometry (relative and/orabsoluteproteinquantification)

• Experience with mass spectrometry-based covalent screening, and provenexpertisewith IP-MS or chemical probe-basedenrichment MSworkflows,andexperiencedeveloping automated processes to analyzelarge numberof samplesforMS analysis

• Skilled ininvestigatingcompound effectsunder biochemical and cellular settingswith quantitativemass spectrometry,e.g.PTMs, protein complexes perturbations,etc

• Experience indeterminingprotein abundanceand turnoverby using quantitative proteomicstechnologies, such as TMT, SILAC,and/orlabel-free approaches and data independent acquisition (DIA)

• Expertisein data analysis and an ability to communicate data interpretation clearly

• Significant external reputation gained through professional recognition, externalpresentationsand publicationsin high-impact journals

• Ability to contribute with a positive, result oriented andproblem-solving attitude

Desirable Requirements

• Experience in pre-clinical drug discovery

• Experience usingThermoQ-Exactive,OrbitrapExploris,Eclipse,AstralZoomorTimsTOF

• ExperiencewithXcalibur, Proteome Discoverer,MaxQuant, Skyline,Spectronautand DB search engine tools

• Experience with liquid handling systems and robotic automation

• Familiarity with targeted proteomics is a plus

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There is no better place tomake a difference to medicine,patientsand society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning,growthand development.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feelwell qualifiedfor this opportunity.  If you know someone who would be a great fit, please share thispostingwith them.