Research Scientist / Senior Research Scientist, Chemical Biology & Proteomics

We are seeking a highly motivated and dedicated scientist to join our Chemical Biology & Proteomics (CBP) team at AstraZeneca in Waltham, MA. As a Research Scientist / Senior Research Scientist, you will be an integral member of a team generating pre-clinical pharmacology data to understand efficacy and selectivity of therapeutics agents. You will have the opportunity to work with a team of cross functional scientists and support the development of new and successful therapies for patients. If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

Key Responsibilities

• Develop and employ chemical tools and proteomics technologies to provide impactful mechanistic insights for drug discovery projects across therapeutic areas
• Design and complete experimental plans to understand target engagement and selectivity profiles of therapeutic agents
• Develop mass spectrometry-based methods to understand drug-induced proteome dynamics and investigate post-translational modifications (PTM)
• Represent CBP team, and communicate with project subject area leads, and contribute to generation of mechanistic hypothesis through interpretation of sophisticated proteomics data
• Maintain and troubleshoot LC-MS system

Essential Requirements

• M.S. in Analytical Chemistry, Biochemistry or a related field (RS), or PhD with 2+ years of post-doctoral/industrial experience (SRS)
• Knowledge and hands-on experience with sample preparation and method development on quantitative mass spectrometry (relative and/or absolute protein quantification)
• Proven expertise with IP-MS or chemical probe-based enrichment MS workflows, and experience developing automated processes to analyze large number of samples for MS analysis
• Skilled in investigating compound effect under biochemical and cellular settings by quantitative mass spectrometry, e.g. PTMs, protein complexes perturbations, etc
• Experience in determining protein abundance and turnover by using quantitative proteomics technologies, such as TMT, SILAC, and/or label-free approaches and data independent acquisition (DIA)
• Expertise in data analysis and an ability to communicate data interpretation clearly
• Significant external reputation gained through professional recognition, external presentation and publication in high-impact journals
• Ability to contribute with a positive, result oriented and problem-solving attitude

Desirable Requirements

• Experience in pre-clinical drug discovery
• Experience using Thermo Q-Exactive, Orbitrap Fusion Lumos, Exploris, Eclipse, or TimsTOF
• Experience with Xcalibur, Proteome Discoverer, MaxQuant, Skyline, Spectronaut and DB search engine tools
• Experience with liquid handling systems and robotic automation
• Familiarity with targeted proteomics is a plus

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and ignite your entrepreneurial spirit. There is no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a phenomenal fit, please share this posting with them.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.