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Senior Research Scientist, Bioinformatics

Location Oss, North Brabant, Netherlands Job ID R-195361 Date posted 19/03/2024

Acerta Pharma, operating as a Haematology/Oncology research and development hub for AstraZeneca, offers an exciting opportunity for a Research Scientist Bio-informatics at our (brand new) research facility in Oss, The Netherlands. 

We have a job opportunity available for a highly skilled postdoctoral scientist specialising in cutting-edge Bioinformatics with a profound focus on cancer genomics, and preferably experience in the hemato-oncology. 

This role involves collaboration within our BioScience Discovery team and synergistic engagement with Bioinformaticians across AstraZeneca's R&D sites in Waltham (Boston, USA) and Cambridge (UK). Committed to pioneering advancements in cancer treatment, we aspire to lead the way in developing next-generation therapies for the benefit of cancer patients worldwide.

Senior Research Scientist, Bioinformatics
Pivot Park, Oss, Netherlands

Your challenge
As a Senior Research Scientist Bioinformatics, you will play an important role in the discovery of novel innovative medicines for haematologic malignancies. You will be responsible to drive top-notch bioinformatic analyses and screens, based on publicly available datasets as well as the design, processing and analysis of in-house generated multi-omics and functional CRISPR-generated datasets

In this position (as part of a broader global discovery team):
•    You will work with postdoctoral biologists and chemists in Oss and Waltham in sharing knowledge, provide coaching and bioinformatic support on experimental designs, data acquisition and analyses of high-throughput multi-omics datasets.
•    In relation to the pathobiology of haematological malignancies, you are the expert and adopt a leading role in the development and execution of data analysis strategies to identify tumour drivers and biomarkers of therapy response or therapy resistance as starting points.
•    You will keep up-to-date with novel developments in the field to maintain a high level of expertise with Bioinformatic and IT technologies.
•    You will develop and maintain an in depth understanding of the scientific and technological domains supported by the team and you have, or willing to develop, a good understanding of the pharmaceutical drug discovery process.
•    You will build scalable cloud-based or high performance computing solutions that work on tens-of-thousands of CPUs.

What you bring
•    PhD degree in Biology with a high-expert level in Bioinformatics, Computational Biology or Bioinformatics with proven Postdoctoral experience (min 3 years) in data analyses of cancer-related multi-omics datasets.
•    Proven track record of successful implementation of bioinformatics tools for scientific data management and analysis of large datasets such as machine learning, graph modelling and Bayesian analytics or other state-of-the-art approaches (e.g. from next generation sequencing applications and gen/protein interactions works, Omics-type data) and harmonising different types of data sets for analyses. 
•    Experience in the design, development, optimisation, and scaling of informatics applications and solutions. 
•    Expertise in querying, mining and interpreting cancer variants from public resources (TCGA, CBio-Portal).
•    Expertise in differential gene expression analyses and pathway enrichment tools.
•    Strong interpersonal skills  to effectively team-up in a global organisation with a broad range of scientists across multiple disciplines.
•    Excellent communications in English (both written & spoken).

What do we offer
•    A dynamic, innovative, growing and international working environment in a global science-driven organisation with a leading role in developing novel treatments for Haematological malignancies. 
•    The opportunity to work in a vibrant, diverse and international BioScience team, where you can learn and grow and have the opportunity to play a key role in the discovery and development of future medicines that make a difference in patient lives. 
•    Good salary and benefits including 8% holiday allowance, 25 days holiday (full time basis). Collective pension with fixed percentage own contribution, bonus scheme. As well-being of our colleagues is important to us, we offer Fisc-free arrangements for discounts on sport memberships, bicycle purchase, etc.

For expat candidates who are already living in Europe we offer
•    a relocation package (including support for the application to the tax authorities for the 30% tax ruling).
•    an expat program, including a Dutch language course and the opportunity to learn more about the Dutch culture.

Acerta Pharma
At our international headquarters in Oss, the Netherlands, we are working to develop new treatment options for patients with specific types of blood cancer. Together with our colleagues of AstraZeneca in US, Canada and UK we are committed to innovative drug discovery and development, especially in the field of haematological oncology.

Acerta has received approval from both the US (FDA) and the European Regulator (EMA) for its small molecule BTK inhibitor for treatment of patients with chronic lymphocytic leukaemia (CLL). In addition, AstraZeneca and Acerta Pharma are collaborating on a large number of other innovative medicines to treat haematological malignant diseases.

How to apply:
We would like to receive your resume (Curriculum vitae) in English. For this, go to the apply button at the bottom of this vacancy.

If you have any questions about this vacancy, our Recruitment team (Karin Raadschelders, Caroline van Oppen) can be reached via or on +31(0)85 - 047 0244.

Acquisition by recruitment and selection agencies is not appreciated.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

50056710 D SCBO

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