Oligonucleotide Chemistry Process Development Internship - New Modality Chemistry

Oligonucleotide Chemistry Process Development Internship - New Modality Chemistry

Macclesfield

AstraZeneca is a global, science-led biopharmaceutical business and its innovative medicines are used by millions of patients worldwide! AstraZeneca Summer Internships introduce you to the world of ground-breaking drug development, embedding you in highly dedicatedteams,committed to delivering life-changing medicines to patients. Our 10–12-week program is designed for undergraduate, master's, and doctoral students. We offer exciting opportunities across Research & Development, Operations, and Enabling Units (Corporate functions).

Our internships immerse students in the pharmaceutical industry, allowing the opportunity to contribute to our diverse pipeline of medicines whether in the lab or outside of it! You will feel trusted and empoweredtotakeonnewchallenges, but with all the help and guidanceyouneedtosucceed. This internship will help you developessential skills, expand your knowledge, and build a network that will set you up for future success. You will be surrounded by curious,passionate, and open-minded professionals eager to learn and follow the science, fostering your growth in a truly collaborative and globalteam.

AstraZeneca has partnered with the Royal Society of Chemistry’s Broadening Horizons intheChemicalSciences programme, to support chemists from minoritised racial and ethnic backgrounds pursue careers inthechemicalsciences. This internship is being offered exclusively to the Broadening Horizons Cohort to support this programme and our commitments to it.

Pharmaceutical Sciences is a function within the AstraZeneca Biopharmaceuticals R&D unit that builds innovative, efficient solutions by transforming molecules into investigative medicines meeting unmet needs of future patients. The function has four departments: EarlyChemicalDevelopment,Advanced Drug Delivery, Early Product Development and Manufacturing and Data Science and Modelling.

EarlyChemicalDevelopment (ECD) is aworldclass CMC department with responsibility for early phase Drug Substance. The department’s responsibilities span from early engagement with Discovery Chemistry groups to manufacture of Phase II Clinical material, and its key skill areas include Analytical Chemistry, Crystallisation, Isotope Chemistry, Large-Scale Laboratory (Kilo-Lab) Manufacturing, Process Chemistry, Process Design, Process Engineering, Route Design and Separation Science.

This role will sit within ECD’s New Modalities team, which has a focus on delivering against our Oligonucleotide projects portfolio, as well as contributing to the implementation of the new process development capability for therapeutic oligonucleotidedrugsubstance.

The role is based at the Macclesfield Campus, Cheshire, and is primarily laboratory based.

This internship offers an exciting opportunity to work across the whole oligonucleotidedrugsubstance workflow in ECD and implement process improvementscontributing towards multiple therapeutic oligonucleotide projects.

The successful candidate will gain an in depth understanding of the solid-phase oligonucleotide synthesis (SPOS) workflow: oligonucleotide synthesis, cleavage & deprotection, ultrafiltration/diafiltration, purification, annealing, lyophilization and analytical analysis. They will get full training and use of the SPOS workflow equipment: CytivaOligoSynth synthesizer, React IR 702L probe, tangential flow filtration system, WavePrep microwave, Cytiva Avant liquid chromatography system, UV-Vis spectrophotometer and freeze drier.

The candidate will work closely with their supervisor and the wider New Modalities Group to develop process improvements in SPOS, and, with supervision, create and execute experimental ideas for process improvements impacting into multiple SPOS projects, reporting results and next steps in weekly technical group meetings.

AstraZeneca is where you can immerse yourself in groundbreaking work with real patient impact.

Trusted to work on important projects, you’ll have the independence totakeonnewchallenges while receiving all the guidanceyouneedtosucceed. Our collaborativeenvironment is designed to help you growprofessionally and personally, surrounded by passionate individuals eager to makeadifference.

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca, starting with the recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics.

We are an equalopportunity employer and value diversity at our company. We donotdiscriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonableaccommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

We offer reasonableadjustments/accommodations to help all candidates to perform at their best. If you have a need for any reasonableadjustments/accommodations, please complete the section in the application form.

Ready to make an impact? Apply now and join us on this excitingjourney!