Scientist, In Vivo Pharmacology

Job title: Scientist, In Vivo Pharmacology

Location: Hamilton, Ontario

Onsite 5 days/week

Fusion Pharmaceuticals, part of the AstraZeneca Group, is redefining precision oncology with next‑generation radioconjugates that deliver powerful alpha‑emitting payloads directly to tumors. Our pipeline spans multiple first‑in‑class programs—backed by a GMP‑compliant, pioneering radiopharmaceutical facility in Hamilton, we’re turning modern science into real‑world impact for patients. Join us at the forefront of radiopharma innovation and be part of turning breakthrough science into meaningful outcomes for patients—come build what’s next with us!

The Role

As a Scientist in the In Vivo Pharmacology group, you will play a central role in advancing our radioconjugate drug discovery portfolio. Based primarily in the lab at our Hamilton site, you will build, execute, and interpret in vivo studies that evaluate the efficacy, safety, and pharmacokinetics of novel radioconjugate agents in preclinical disease models. You will work both independently and as an integral member of cross-functional project teams, directly supporting programs from early discovery through candidate selection.

Duties/Responsibilities:

• Plan and conduct radiopharmaceutical in vivo studies (biodistribution, efficacy, PK/PD) end-to-end in rodent models of cancer or other disease indications of interest with a high degree of competence. This includes cell culture, in-life monitoring, dosing (IV, IP, subcutaneous, oral gavage), blood sampling, necropsy and tissue dissections. Conduct ex vivo analysis as needed (flow cytometry, IHC, autoradiography, biochemical assays).
• Implement and assess new pharmacology models, technologies, and strategies to develop targeted radiotherapies.
• Maintain meticulous records and documentation with high attention to detail, ensuring compliance with regulatory requirements and internal standards
• Work both autonomously and closely with cross-functional collaborators to provide practical expertise and data package to support key decision-making
• Write and review study documentation, analyze results, and contribute to authoring manuscripts and regulatory filings
• Contribute to protocol development, regulatory compliance (radiation safety and animal welfare), and continuous improvement of laboratory workflows.
• Work safely and in compliance with radioactive, biohazardous, animal ethics regulations and guidelines
• Foster an environment of collaboration, scientific excellence, open scientific exchange, and deep scientific rigor

Essential Qualifications:

• Bachelor’s/Master’s degree in Molecular/Cell Biology, Biology, Biochemistry or related field with 2+ years of preclinical pharmacology experience
• Proven hands-on experience designing and performing in vivo pharmacology studies required (experienced with IV, IP, subcutaneous injections, oral gavage, blood collection via tail, saphenous or facial, necropsy and tissue dissections)
• Experience with xenograft and syngeneic tumor models (tumor implantation, caliper monitoring, IVIS)
• Must be agile and able to adjust, with demonstrated ability to manage concurrent timelines and deliverables
• Demonstrate strong attention to detail and a commitment to resolving issues
• Strong record of working independently in the lab while also contributing effectively to cross-functional team efforts in a dynamic, fast-paced environment.
• Strong documentation and record-keeping skills required

Desirable:

• Biotech or pharmaceutical industry experience
• Experience with the safe handling of radioactive and biohazardous materials

Great People want to Work with us! Find out why:

• GTAA Top Employer Award for 11 years
• Top 100 Employers Award
• Canada’s Most Admired Corporate Culture
• Learn more about working with us in Canada
• View our YouTube channel

Are you interested in working at AZ, apply today!

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing AZCHumanResources@astrazeneca.com.

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Annual base salary for this position ranges from 82,377.60 to 108,120.60.

AstraZeneca is committed to providing fair and equitable compensation opportunities to all colleagues. Our compensation policies and practices have been designed to allow colleagues to progress through the salary range over time as they progress in their role. The range provided in this posting represents an offer pay range used in a majority of situations. The base pay offered will vary depending on multiple individualized factors, including the candidate's skills and experience, job-related knowledge, and other specific business and organizational needs.  In some cases, offers outside the range may also be considered to address unique circumstances.

In addition, our permanent positions offer an annual Variable Pay Bonus/Short Term Incentive opportunity as well as eligibility to participate in our equity-based long-term incentive program (if applicable to role).  Benefits offered for permanent roles include a competitive Flex Benefits & Retirement Savings Program, 4 weeks’ paid vacation, and annual Personal Days. Fixed Term Contract/Temporary positions (excluding students) are offered a Contract Benefits Program.

We are using AI as part of the recruitment process.

This advertisement relates to a current vacancy.