DMPK Project Leader - Respiratory & Immunology (R&I)

Are you an experienced drug discovery scientist with expertise in drug metabolism and pharmacokinetics (DMPK) and pharmacokinetic/pharmacodynamic (PKPD) modelling across multiple modalities? Would you like to apply your expertise in a global company that follows the science and turns ideas into life-changing medicines? Then you could be the new colleague we are looking for!

We are looking for an experienced and driven individual to join our team as a DMPK Project Leader (Associate Principal/Principal Scientist depending on your level of professional experience). The position is located at AstraZeneca’s dynamic R&D site in Gothenburg, Sweden, a world-class facility with state-of-the-art laboratories and shared spaces to accelerate decision making and problem solving while benefiting from the Swedish focus on work-life balance. The working language is English, and the site is a multicultural environment with scientists from over 70 countries.  

Respiratory & Immunology (R&I) is one of the three main therapeutic research areas within AstraZeneca. R&I has research units in Gaithersburg (US), Cambridge (UK) and Gothenburg (Sweden), and delivers candidate drugs into late-stage clinical development. Working at R&I DMPK means being entrepreneurial, following the science, scrutinizing data and details, combined with holistic thinking and achieving progress through teamwork within DMPK and between functions across sites. DMPK supports projects from target selection to market launch and Life cycle management.

What you’ll do:With a true passion for drug discovery and development you will support our R&I portfolio. The DMPK Project Leader role is a strategic and scientific role, in which you will work collaboratively with project representatives from other disciplines. These may include biology, antibody Discovery/Protein Engineering, medicinal chemistry, safety, clinical pharmacology, and pharmaceutical sciences, where your task is to influence candidate profiling by providing the necessary DMPK input and data to support clinical investigations and regulatory submissions.

It is your responsibility to ensure delivery and interpretation of all DMPK related activities like preclinical PK and distribution experiments, in vitro ADME and biotransformation, assisting design of pharmacodynamic studies, DDI risk assessment, PKPD analysis and human dose prediction from candidate selection through life cycle management. You have a solid understanding of DMPK throughout the value chain (discovery and development), a working knowledge of pharmacology and PKPD, and can provide expert advice and interpretation of complex drug discovery data in relation to regulatory guidelines.

Main Duties and Responsibilities will include:•    Deliver DMPK strategy, input and data to projects within agreed timelines and to the right quality•    Apply an understanding of DMPK to support/influence compound profiling, project progression and project strategy•    Define and deliver a translational quantitative PKPD strategy in projects, so that effective conclusions can be made•    Contribute to estimation of safety margins and report results and interpretations to project teams and internal governance bodies•    Responsible for leading, coordinating and engaging with R&I DMPK colleagues as well as cross-functionally in project related activities•    Prepare clear presentations related to the above for internal governance bodies•    Contribute to further DMPK science together with colleagues•    Communicate scientific progress both externally and internally Essential requirements:•    PhD (or equivalent experience) in a relevant scientific field•    Deep expertise in DMPK sciences with comprehensive knowledge of the drug discovery and development processes•    Broad experience across different modalities including small molecules and biologics (PK & Bioanalysis) and curious about novel modalities•    Regulatory submission experience for both biologics and small molecules and familiarity with global regulatory guidelines (e.g., ICH, FDA, EMA)•    High level of knowledge and skill in pharmacokinetics in addition to (at least) basic PK and PKPD modelling skills and mechanistic understanding of drug-drug interaction risk assessments. •    Good knowledge of DMPK assays and their implications and proficiency within silico tools for PK prediction•    Proven project leadership and mentoring junior scientists •    Work independently but with a collaborative mindset and good written and verbal communication skills in English•    Proactive, team-oriented approach to problem solving

Why AstraZeneca? At AstraZeneca, we're dedicated to being a Great Place to Work. You'll be empowered to push the boundaries of science and unleash your entrepreneurial spirit.  This role offers the chance to lead significant scientific advancements in a country known for its innovation and high quality of life.

We offer: • Impact: Direct influence on medicines that change patient lives • Collaboration: An inclusive culture that champions diversity  • Growth: Commitment to lifelong learning and career development • Innovation: Work on a rich and diverse pipeline of with molecules across many different modalities

There's no better place to make a difference to medicine, patients, and society. Join us on our exciting journey to pioneer the future of healthcare.

Work policy:When we put people in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. This role is located in Gothenburg, Sweden and is not available for remote work or with travel or commuting support.

What's next?If this sound like the position and place for you - apply today!We look forward to receiving your application, but no later than May 31, 2026. The interview process will be ongoing, so don’t hesitate to apply early.

Additional information:Our Gothenburg siteLife in Gothenburg, SwedenAbout AstraZeneca R&D

Date Posted

18-maj-2026

Closing Date

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.