Senior Scientist

Senior Scientist

Introduction to role

We are seeking a highly motivated Senior Scientist with extensive expertise in cancer immunology/immunotherapy. The successful candidate will have substantial experience in studying T cells and myeloid cells both in vivo and in vitro, with a specific interest in myeloid cell progenitors and/or lipid metabolism. You will independently design and execute projects/experiments, troubleshoot and optimize methods, and generate, interpret, and report scientific data clearly and concisely. A PhD in Immunology or a related field and a proven postdoctoral record with strong publications are required. Strong expertise with mouse tumor models is desirable. This is an onsite role requiring 5 days per week of onsite presence.

As a Senior Scientist in our Oncology R&D department, you will be a key member of a team focused on designing novel therapeutics to target myeloid biology and immunotherapy, supporting projects through the drug discovery and development process. You will bring your theoretical and practical expertise in immunology to establish assay systems and deliver datasets that will have a direct impact on immune-oncology therapeutics. 

Accountabilities

• Independently conduct mechanistic cancer immunology and drug discovery research experiments using techniques in immunology, molecular, and cellular biology 

• Assess and report data with little guidance in a clear and concise manner with a strong understanding of its implications within the overall context of drug discovery 

• Maintain a well-developed understanding of approaches to investigate the function of myeloid cells and aspects of drug discovery 

• Actively liaise between programs/departments, sharing scientific knowledge and feedback on others’ experiments to ensure efficient relay of information and translation of data 

• Ensure own work and work of peers is compliant with Good Laboratory Practice, Safety, Health, and Environment standards, and all other relevant internal AstraZeneca standards and external regulations 

• May be asked to lead or co-lead a project team and contribute to scientific publication goals 

Essential Skills/Experience

• A PhD in immunology, cancer biology, or related field with minimum of 2 years of experience 

• Extensive experience in studying T cells or myeloid cells: MDSC, macrophages, dendritic cells, expertise or knowledge of peptide vaccines 

• Strong hands-on skills in basic biochemical and immunological methods including multi-color flow cytometry (FACS), ELISA/multiplex assays, western blotting, luminescence assays, cell killing assays, high content imaging 

• Excellent organizational and communication skills 

• Ability to work in a high-paced team environment, plan and meet timelines 

• Proven track record of success in your research, and experience preparing written scientific reports (e.g., manuscripts) and oral presentations to broad and diverse audiences

Desirable Skills/Experience

• In vivo expertise in murine tumor models 

• Experience developing cancer immunotherapy including cancer vaccines and cellular therapies 

At AstraZeneca, we follow the science and pioneer new frontiers. Join our team dedicated to Oncology with an ambition to eliminate cancer as a cause of death. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Fusing cutting-edge science with the latest technology to achieve breakthroughs. Backed by investment, we aim to deliver 6 new molecular entities by 2025. Our environment is built on courage, curiosity, and collaboration. We make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team. Pioneers of collaborative research, we have built an unrivalled scientific community both internally and externally. Working seamlessly together, we expedite research in some of the hardest-to-treat cancers. Have the opportunity to build a rewarding career as part of the team committed to improving the lives of millions with cancer. 

Ready to make a difference? Apply today! 

The annual base pay for this position ranges from $108,474 to $162,710. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.