Scientist

Join AstraZeneca's InVivoDiscovery Platforms group within the Biologics Engineering department, where we are pushing the boundaries of science to deliver life-changing medicines. Our passion for discovery drives us to explore novel therapeutic approaches across various diseases, including Oncology, Respiratory, Cardiovascular, and Infectious diseases. As part of our collaborative network, you will have the opportunity to engage with new and exciting technologies that are transforming patient care.

Accountabilities:

As a key member of the team, you will design and executein vivostudies, interpret pharmacokinetic (PK) data, and develop and qualify PK assays to supportdiscoveryprogramsand novel platform technologies. You will evaluate panels of lead candidatesin vivo, deliver high-quality PK datasets, and collaborate closely withcross‑functionalpartners to inform data-driven decision making across programs. Your strong work ethic, exceptional organization, and clear communication will be critical to delivering impact and advancing our portfolio.

In this role, you will:

• Complete wet-lab experiments (80%) and data analysis(20%).

• Design and executein‑vivoPK studies across relevant species; coordinateanimaldosing, sampling, andlogistics; ensure data integrity and compliance with internal SOPs and applicable guidelines.

• Develop,qualify, and, whererequired,validatePK bioanalytical assaysfitfor purpose across discovery and regulated contexts.

• Perform PK sample analysis, troubleshoot assays, and deliverhigh‑qualitydatasets within agreed timelines; ensureappropriate controlsand documentation for traceability.

• Collaborate within‑vitro,in‑vivo, and bioanalysis scientists to build research plans and align on study designs; present data and recommendations to project teams and department leadership.

• Identifyopportunities to streamline workflows, implement best practices, and adoptnew technologiesto improve throughput, quality, and decision speed.

• Assistwith cell culture, including routine maintenance and expansion.

• Work within a matrixed environment across multiple groups.

Essential Skills/Experience:

Educational requirements:

BS (5+ years) or MS (2+ years) withhands‑onexperience in animal handling, bioanalysis, pharmaceutical sciences, or a closely related discipline.

Required skills:

• Strong background in immunochemical and /or cell-based assays, including experience with cell culture techniques,high throughput flow cytometry,ligand-binding,ELISA ,MSDas well as other novel bioanalytical techniques and platforms.

• In‑VivoPK Expertise:Hands‑onexperience planning and executing PKin‑vivostudies, includinganimaldosing, sampling, and PK sample handling; understanding of species selection, exposure targets, and PKprinciples.

• Bioanalytical Skills: Practical experience with PK assay development and qualification (e.g.,ligand‑bindingassays such as ELISA/ECL); familiarity with regulated bioanalysis expectations.

• Data and Tools:Proficiencywith PK data processing.

• Communication and Collaboration: Strong written and verbal communication skills;demonstratedability to present PK/bioanalytical results to multidisciplinary teams.

• Organization and Execution: Proven ability to manage multiple studies in parallel, meet timelines, andmaintainmeticulous documentationin accordance withSOPs and quality standards.

Desirable Skills/Experience:

• Laboratory experience withGxPregulations, documentation, regulatory guidance, and regulatory submission. 

• Understanding of immunogenicity assessments and their impact on PK; experience with biologics modalities (e.g.,mAbs,bispecifics, ADCs, peptides, nucleicacid‑basedtherapies).

• Familiarity with spreadsheet, word processing, and graphical computer programs (e.g.Excel, Word, GraphPad Prism, etc.)andexperience with electronic notebook keeping and data entry usingGenedataBiologics

AstraZeneca is where bold thinking meets relentless curiosity. Our ambition to transform outcomes across oncology, respiratory and immunology (R&I), cardiovascular, renal and metabolism (CVRM), and infectious disease drives us to harness advanced science and technology. Withhigh‑qualitymolecules across multiple indications and every stage of development, we make decisive,patient‑firstchoices that accelerate impact. Our collaborative ecosystembrings together diverseexpertiseto tackle some of the most challenging diseases. Here, you can build a fulfilling career focused on improving the lives of millions of patients worldwide.

Ready to shapewhat’snext? Apply today to join our team.

The annual base pay (or hourly rate of compensation) for this position ranges from $92,252 to $138,378]. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.