Project Manager – PMO (GMP & non-GMP)

Summary of Role:

The Project Manager – PMO is responsible for end-to-end delivery of complex capital and infrastructure projects across AstraZeneca’s U.S. R&D network, including GMP and non-GMP facilities. 

This role leads projects from early concept through closeout, partnering with Site Leadership and Global stakeholders to define scope, evaluate infrastructure capacity and impacts, assess risk, and shape capital strategy early in the lifecycle. The Project Manager ensures initiatives are aligned with site strategy and executable within active, regulated environments. 

This role provides full project lifecycle accountability — scope, budget, schedule, risk, governance, and stakeholder alignment — ensuring delivery of safe, compliant, and operationally sustainable facilities. 

The Project Manager leads cross-functional teams including Project Engineers, external design firms, contractors, Quality, SHE, and Facilities to ensure projects are executed with operational excellence and regulatory integrity. 

Responsibilities:

• The Project Manager – PMO is responsible for end-to-end delivery of complex capital and infrastructure projects across AstraZeneca’s U.S. R&D network, including GMP and non-GMP facilities. 

• This role leads projects from early concept through closeout, partnering with Site Leadership and Global stakeholders to define scope, evaluate infrastructure capacity and impacts, assess risk, and shape capital strategy early in the lifecycle. The Project Manager ensures initiatives are aligned with site strategy and executable within active, regulated environments. 

• This role provides full project lifecycle accountability — scope, budget, schedule, risk, governance, and stakeholder alignment — ensuring delivery of safe, compliant, and operationally sustainable facilities. 

• The Project Manager leads cross-functional teams including Project Engineers, external design firms, contractors, Quality, SHE, and Facilities to ensure projects are executed with operational excellence and regulatory integrity. 

Project Leadership & Accountability

• Lead front end planning: scope definition, feasibility, infrastructure capacity assessments, and cost modeling. 

• Translate business needs into clearly defined charters, scope, and key assumptions. 

• Develop and defend capital investment business cases, incorporating cost, risk, and lifecycle considerations.  

• Identify enabling projects, sequencing constraints, and long-term site impacts during early planning. 

• Execute capital projects from initiation through closeout. 

• Own project scope, budget, schedule, and risk profile. 

• Develop business cases and capital authorization packages. 

• Manage capital forecasts and financial tracking. 

• Ensure projects align with long-term site master planning strategy. 

Governance & Compliance

• Ensure adherence to PMO governance framework and stage-gate processes. 

• Establish early-stage risk identification and mitigation strategies to reduce downstream execution uncertainty. 

• Execute risk assessments and mitigation planning. 

• Manage contingency planning and formal change management to protect cost and schedule commitments.  

• Ensure regulatory, safety, and environmental compliance throughout execution. 

• Escalate and resolve project risks impacting cost, schedule or operational readiness. 

Stakeholder & Cross-Functional Leadership

• Serve as primary project interface for Site Leadership and Global stakeholders. 

• Align Engineering, Quality, SHE, Procurement, and Operations. 

• Lead steering committee updates and executive reporting. 

• Drive strong collaboration between GMP and non-GMP pillars. 

Contractor & Vendor Management

• Lead selection and oversight of design firms and contractors. 

• Negotiate scope changes and manage contract performance. 

• Ensure safe execution and adherence to project controls. 

GMP & Technical Integration

• Partner with Project Engineers to ensure technical rigor.

• Ensure validation and regulatory expectations are integrated early in project lifecycle. 

• Oversee commissioning and qualification strategy alignment. 

Portfolio & Strategic Contribution

• Support capital prioritization decisions through project definition and cost clarity. 

• Identify project interdependencies and sequencing risks across the capital portfolio. 

• Contribute to multi-year capital planning. 

• Identify program-level efficiencies and standardization opportunities. 

• Drive sustainability integration across project portfolio. 

Essential Education and Experience:

• Bachelor’s degree in Engineering, Construction Management, or related field. 

• 5+ years of experience in capital project delivery in pharmaceutical/biotech or similar regulated industry. 

• Proven experience managing projects >$2M. 

• Strong financial acumen and capital governance experience. 

• Experience leading cross-functional, multi-disciplinary teams. 

• Strategic Project Leadership 

• Financial & Capital Management 

• Executive Communication 

• Risk & Governance Discipline 

• Regulatory Awareness 

• Organizational Influence 

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $86.816 to $133,224. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.  

Why AstraZeneca:

Here you will help turn a rich, complex pipeline into real treatments by uniting science, disciplined execution, and smart digital tools. You will collaborate with unexpected teams that challenge ideas and accelerate progress, learning alongside peers who value kindness as much as ambition. With investment in cutting-edge capabilities and a clear focus on speed, quality, and sustainability, your leadership will shorten the path from study start-up to submission and, ultimately, to patients who need our medicines.

Call to Action:

Step forward to lead the clinical programs that shape the next wave of medicines—send your CV today and help us deliver impact at speed!

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.