Scientist (Protein Expression and Large-Scale Purification)

Introduction to role:

Are you ready to scale recombinant proteins from 50–500 L and see your work translate into clinical readiness? Do you thrive at the interface of hands-on experimentation and pilot-scale decision making that speeds life-changing medicines to patients?

As a Scientist in Protein Expression and Large-Scale Purification, you will join a cross-functional team focused onprogressingbiologics from lab to pilot scale with precision, pace and scientific rigor. Your work will underpin toxicology supply, informclinicalmanufacturing strategies, and advance novel technologies that make our processes faster, more robust and more sustainable.

You will collaborate with experts across processdevelopment, analytical sciencesand formulation, working with modern pilot-scale systems to build scalable, high-quality purification processes. Your impact will be visible in the speed and quality of programs entering the clinicand, in the technologies,we develop for the next generation of biologics.

Accountabilities:

• Primary Clarification Operations: Lead primary clarification of 50–500 L bioreactors using disk stack centrifugation and depth filtration.

• Pilot-Scale Purification: Run recombinant protein purification on Bioprocess and AKTA pilot-scale systems.

• Polishing Development: Design and implement polishing steps to enrich purity and remove process- and product-related impurities, increasing product quality.

• Scale-Up for Clinical Readiness: Execute detailed production at scale prior to clinical manufacture, generating data thatsupportstech transfer.

• Ultrafiltration/Diafiltration: Perform UF/DF using bench and pilot-scale systems to achieve target concentration and buffer conditions while maintaining product integrity.

• Analytics and Characterization: Apply SEC-HPLC, UV-Vis, osmolarity and related techniques to characterize process performance, enabling data-driven decisions.

• Technology Development: Contribute to in-house technology development projectsto elevate capability, reduce cost, and increase speed to clinic.

• Data Integrity and Reporting: Record experiments accurately and on time; produce clear data summaries and reports that drive program decisions and meet project timelines.

• Scientific Communication: Present results and recommendations at group and departmental forums, fostering discussion that sharpens strategy and execution.

• Mentorship and Collaboration: Oversee and mentor students from placements or academic collaborations; cultivate productive collaborations internally and with external partners.

• Technical and practical understanding of Protein purifications at 50-500L scale