Principal AI Engineer - Evinova

Job Title: Principal AI Engineer - Evinova
Location: Boston, MA

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office is purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects. 

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release

Are you ready to be part of the future of healthcare? Can you think big, be bold, and harness the power of digital and AI to tackle longstanding life sciences challenges?  Then Evinova, a global health tech business might be for you!  

Transform patients’ lives through technology, data, and innovative ways of working. You’re disruptive, decisive, and transformative. Someone excited to use technology to improve patients’ health. We’re building a new Health-tech business – Evinova, a fully-owned subsidiary of AstraZeneca Group.

Evinova delivers market-leading digital health solutions that are science-based, evidence-led, and human experience-driven. Thoughtful risks and quick decisions come together to accelerate innovation across the life sciences sector. Be part of a diverse team that pushes the boundaries of science by digitally empowering a deeper understanding of the patients we’re helping. Launch pioneering digital solutions that improve the patients’ experience and deliver better health outcomes. Together, we have the opportunity to combine deep scientific expertise with digital and artificial intelligence to serve the wider healthcare community and create new standards across the sector. 

Introduction to Role:

As Principal AI Engineer, you'll design and implement sophisticated agentic AI systems that power next-generation life sciences solutions. Working at the intersection of AI research and real-world healthcare applications, you'll build intelligent agents that can reason, plan, and act autonomously to solve complex clinical challenges.

What makes this role compelling:

• Lead challenging projects in agentic AI, LLM orchestration, and multi-agent systems
• Build AI agents that directly impact clinical trials, drug discovery, and ultimately patient care
• Collaborate with product teams, clinical experts, and ML engineers in a fast-paced environment
• Develop automated evaluation systems, prompt optimization techniques, and advanced agent architectures
• Contribute to the AI in life sciences community through publications, conferences, and open-source work

Example impactful projects include: Intelligent AI agents for clinical document generation, advanced search systems for medical research, clinical trial optimization tools, synthetic patient data generation, and multi-modal healthcare AI assistants.

Accountabilities:

• Design Advanced AI Systems
  • Build and deploy sophisticated agentic AI solutions using state-of-the-art LLMs
  • Develop novel approaches to agent memory, tool use, and multi-agent collaboration
  • Build sophisticated NLP systems for retrieval, information extraction, structured generation, graph reasoning.
• Drive Technical Innovation
  • Create automated techniques for agent design, evaluation, and optimization
  • Systematically discover and validate effective prompt engineering approaches for agentic systems
  • Build specialized observability pipelines for continuous model and agent performance monitoring
• Lead Cross-Functional Collaboration
  • Partner with product, design, and clinical teams to translate AI capabilities into impactful healthcare solutions
  • Mentor engineers and contribute to AI strategy across the organization
• Contribute to the Field
  • Share expertise at conferences and through technical publications
  • Contribute to open-source projects and help advance best practices in healthcare AI

Essential Skills/Experience:

• Master's Degree in a relevant field (such as mathematics, computer science, data science).
• 4+ years of industry experience in applied machine learning, with a strong focus on deep learning, NLP, and generative AI.
• Extensive prior experience exploring and testing language model behavior, prompting and building products with language models.
• Expert knowledge of Python and advanced ML/LLM frameworks (e.g., TensorFlow, PyTorch, Google ADK, Crewai,  LangChain, LlamaIndex)
• Extensive experience with AWS services (e.g. SageMaker, Bedrock, MSK, EKS, ECS, OpenSearch).
• Deep understanding of agentic AI systems and frameworks (e.g. agentic design patterns, multi-agent systems, reinforcement learning).
• Excellent communication skills with the ability to articulate complex technical concepts to both technical and non-technical audiences

Desirable Skills/Experience:

• Ph.D. in a relevant field (such as mathematics, computer science, data science).
• Demonstrated technical leadership experience, including successful delivery of large-scale AI projects.
• Experience developing complex agentic systems using LLMs.
• Experience with low-level languages used for implementing high-performance ML code (C/C++, Rust, CUDA, etc.)
• Contributions to open-source AI projects or development of proprietary AI frameworks.
• Expertise in areas such as few-shot learning, meta-learning, explainable AI.
• Experience with AI ethics, responsible AI practices, and navigating regulatory landscapes for AI deployment in the life science industry.

Where can I find out more?

• Learn more about Evinova www.evinova.com
• Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
• Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
• Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
• Our US Footprint: Powering Scientific Innovation - YouTube

Why Evinova?

Evinova is a global health tech business, separate company part of the AstraZeneca group. Together, we can accelerate the delivery of life-changing medicines, improve the design and delivery of clinical trials for better patient experiences and outcomes, and think more holistically about patient care before, during, and after treatment.  We know that regulators, healthcare professionals, and care teams at clinical trial sites do not want a fragmented approach. They do not want a future where every pharmaceutical company provides its own, different digital solutions. They want solutions that work across the sector, simplify their workload, and benefit patients broadly. By bringing our solutions to the wider life sciences community, we can help build more unified approaches to how we all develop and deploy digital technologies, better serving our teams, physicians, and ultimately patients.  Evinova represents a unique opportunity to deliver meaningful outcomes with digital and AI to serve the wider healthcare community and create new standards for the sector.  Join us on our journey of building a new kind of health tech business to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting-edge methods, and bringing unexpected teams together. Interested? Come and join our journey.

Total Rewards:

The annual base pay (or hourly rate of compensation) for this position ranges from $144,648.80 to $216,973.20. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing AZCHumanResources@astrazeneca.com.

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Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.