Senior Statistician II

Job Title: Senior Statistician II

Introduction to role:

Are you ready to use sophisticated statistics to shape decisions that directly influence medicines for patients? Do you want your expertise to be visible at the highest levels, from internal governance committees to regulatory interactions?

In this high-exposure role, you will provide statistical leadership that advises study design, strengthens evidence, and guides pivotal choices across global programs. You will join a team that values curiosity and courage, where speaking up, testing bold ideas, and learning from critique drive better outcomes for patients.

You will partner closely with clinicians, data scientists, and cross-functional colleagues, working through unknowns with resilience and a practical approach. Your work will be recognized across the enterprise and externally, and your voice will help shape end results and the standards we use to make decisions.

Accountabilities:

• Statistical Leadership for Sophisticated Designs: Provide statistical expertise for sophisticated design and interpretation for preclinical or clinical programmes, high level internal governance committees, regulatory submissions and/or commercialisation, ensuring decisions are robust and patient-focused.
• Modelling and Simulation: Examine internal and external data, carry out modelling and simulation to guide build decisions and the creation of decision criteria, accelerating assured program progress.
• Analysis Planning: Develop a Statistical Analysis Plan for sophisticated studies and/or project deliveries to align teams and produce reproducible, compliant results.
• Coaching and Guidance: Act as a coach/guide for less experienced statisticians in the production of analysis, supporting graphics and analysis tables for study reports, Global Medical Affairs studies or publications, setting a higher standard on quality and consistency.
• Results Interpretation and Communication: Analyse, interpret, summarise and communicate results of complex studies so collaborators can make clear, evidence-based decisions.
• Regulatory Contributions: Supply to regulatory submissions involving the creation of overview documents and addressing regulatory questions, translating statistical insight into compelling, compliant narratives.
• Identify chances to improve the methodology and recommend actionable strategies for challenges. Recognize and employ statistical methods to improve outcomes in the process and delivery activities.
• Standard Process Development: Support the formulation of procedures aimed at improving quality, efficiency and effectiveness, embedding standards that scale across programs.
• Take responsibility for the quality of your statistical work. Provide discipline-specific insight and thoughtful challenge. Identify development needs and pursue mentor support or training.
• Methodological Innovation: Under guidance of a more expert statistician, produce pragmatic solutions within tight timelines—deliver first, then refine and develop solutions thereafter.
• Consultancy and External Engagement: Provide consultancy within your area of expertise to fellow statisticians and medical scientists; investigate and apply novel statistical approaches; establish standards and procedures; develop and implement new methodology interacting with external scientists; communicate research and results internally and externally through participation at conferences and journal publications.

Essential Skills/Experience:

• Provide statistical expertise for sophisticated design and interpretation for preclinical or clinical programmes, high level internal governance committees, regulatory submissions and/or commercialisation.
• Analyse internal and external information, perform modelling and simulation to advise design decisions and the development of decision criteria.
• Develop a Statistical Analysis Plan for sophisticated studies and/or project deliveries.
• Act as a coach/guide for less expert statisticians in the production of analysis, supporting graphics and analysis tables for study reports, Global Medical Affairs studies or publications.
• Able to analyse, interpret, summarise and communicate results of sophisticated studies.
• Supply to the regulatory submissions including specification of overview documents and response to regulatory questions.
• Find opportunities for the application of modelling and simulation to improve study design.
• Find opportunities to enhance the methodology and offer practical solutions for problems.
• Identify and apply statistical techniques to improve process and delivery activities.
• Supply to the creation of processes aimed at improving quality, efficiency, and effectiveness.
• Accountable for the quality of their statistical work; offer subject-specific knowledge, perspective, and thoughtful critique and manage their development needs independently, seek mentoring or training opportunities.

Desirable Skills/Experience:

• Produces pragmatic solutions under the mentorship of a more experienced statistician. Emphasis is on delivering quickly and improving solutions afterward.
• Draft statistical analysis plans for complex research projects.
• Provide consultancy drawing on your professional skills to colleagues in therapeutically aligned statistics groups, as well as medical scientists and other key roles across the business.
• Explore and implement innovative statistical methods, for relevant statistical issues and/or regulatory mentorship and/or value demonstration.
• Investigate and improve statistical approaches, define criteria and procedure, develop and introduce new methods in collaboration with external scientists.
• Identify new areas where we can supply, developing collaborative relationships with the external scientific/academic community and maintaining academic links.
• Supply to/or lead the creation of a process improvement and/or capability area within the Department.
• Develop a strong understanding of the pharma business/AZ ways of working.
• Share findings and outcomes inside the company and beyond by attending conferences and publishing in journals.

When we put unexpected teams in the same room, we ignite ambitious thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and high-reaching world.

Why AstraZeneca:

Here, statistical leaders are transparent and trusted decision-makers who influence pivotal moments in medicine development. You will work with diverse experts, fuse your skills with innovative approaches, and see your ideas tested, challenged, and celebrated—setbacks included—because they help us reach better solutions. We invest in technology and in people, and we value kindness alongside ambition. Your contributions will be recognized across programs and beyond the company, as you help turn sophisticated data into transparency and move promising treatments toward patients who need them most.

Call to Action:

If you are ready to bring statistical leadership to high-impact decisions and grow your influence where it truly matters, share your CV and tell us how you will make a measurable difference.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.