Associate Director Bioinformatics

Job Title: Associate Director Bioinformatics

Career Level -E

Introduction to Role:

Join us at AstraZeneca as an Associate Director Bioinformatics in our Oncology Business Unit. This role offers a unique opportunity to partner with CPSS scientists across multiple strategic global locations. You will use computational approaches to generate biological insights, enable new computational capabilities, and drive efforts focused on advancing understanding of drug safety and efficacy. This is a rare chance to gain experience in a variety of computational approaches, work with industry leaders, and contribute directly to the development of future drugs across many diseases.

Accountabilities:

As an Associate Director Bioinformatics, you will build in silico capabilities to advance multi-omics technologies that measure transcripts, proteins, and metabolites at both the bulk and spatial levels. You will drive hypothesis generation by applying computational biology approaches, data integration, and combining biological knowledge. You will also implement new predictive capabilities using computational biology to translate omics data into biological insights for predictive safety. Collaboration with academic research groups, leveraging external grants, and contributing to publications in peer-reviewed journals will be part of your role. You will also help educate and train AstraZeneca colleagues in omics data interpretation and related areas and support junior members of staff and postdocs.

Essential Skills/Experience:

• PhD in computational biosciences (e.g., computational biology, bioinformatics, genomics or computer science) is preferred; or MSc (or equivalent) with experience in independent research in high-throughput omics data will also be considered
• Extensive experience in multiple large-scale omics data types, including transcriptomics, proteomics, metabolomics, epigenetics, genomics or CRISPR gene editing data analysis. Skill-sets in additional computational biology domains are a plus.
• Experience developing predictive safety models such as for liver, heart, kidney or lung
• Expertise in data science techniques, such as machine learning and statistical analysis for biological problems
• Strong programming skills in R or Python, together with data visualisation frameworks
• Team player mindset and ability to explain complex topics to scientists from other disciplines
• Demonstrated evidence of leading highly collaborative cross-functional teams
• Prior experience in the biopharmaceutical industry and general understanding of drug development and pharmacology
• Experience in independent scientific research
• Background in computational toxicology and predictive safety, with knowledge of molecular mechanisms of disease or human biomedicine, particularly in a drug safety context
• Knowledge of drug discovery or pharmaceutical development, including new modalities Car-T, ADC, cell and gene therapies, oligonucleotide-based therapeutics.
• Excellent ability to work on multiple projects at the same time

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we're all here to make an impact – to achieve our bold ambition of eliminating cancer as a cause of death. In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our commitment means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. We’re brave disruptors – entrepreneurial, courageous and pioneering in our approach. Here you have the opportunity to step up, take personal accountability and lead changes in our ever-evolving environment.

Are you ready to make a difference? Apply today and join us in our mission to eliminate cancer as a cause of death!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.