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Sr. Global Medical Affairs Leader (Early Assets CVRM)

Location Cambridge, England, United Kingdom Gaithersburg, Maryland, United States Gothenburg, Västra Götaland County, Sweden Job ID R-115552 Date posted 16/08/2021

Biopharmacuticals Medical (BPM) ensures the best patient outcomes by providing healthcare decision-makers around the world with the evidence and confidence they need on AstraZeneca (AZ) therapies.  We support our internal stakeholders with medical strategic insight and expertise, with the aim of achieving scientific leadership, whilst aspiring to be a great place to work keeping patients at the core of everything we do.

In order to accomplish our goals and enable the best patient outcomes, we look for AZ BPM leaders to have five core capabilities and act as role models for our AZ values. These capabilities include:

Track record of building and maintaining a deep and continued connection to medical practice/healthcare delivery Collaborative/matrix management skills with a focus on leading diverse groups (e.g., cultural, geographical, functional) to achieve excellent results in shared goals Well-developed communication and influencing skills with the ability to distill complexity down to what matters most to our stakeholders An ability to think strategically and creatively Business acumen

Reporting directly to an Executive Director (Medical Head) CVRM BPM, the GMAL for Early Assets will help drive evidence and confidence innovation for prioritized assets in the CVRM phase 2/3 portfolio, to enhance disease state understanding and deliver a medical strategy that is competitive for current and future needs. In this role, the GMAL will develop strong working relationships with colleagues across AZ, including those in clinical development, regulatory, early commercial and payor functions, as well as maintaining a tight connection to BPM and in-line brands. The role will require innovative forward thinking, the ability to partner and identify new collaboration opportunities, as well as engagement with a diverse array of partners and Key External Experts (KEEs). The GMAL for Early Assets will be intricately involved in “strat to launch activites,” will be instrumental to ensuring market readiness for our CVRM pipeline, and fundamental to the external recognition of AstraZeneca’s scientific leadership.

Accountabilities/Responsibilities

  • Determination of unmet need and development of disease area strategies
  • Drive the development of Target Product Profiles (TPPs) and Target Product Claims (TPCs) to help shape the clinical development program
  • Develop and implement an Evidence Generation Plan to support a successful product launch
  • Develop individual asset and broader portfolio narratives
  • Input into clinical trial designs and endpoints, with a focus on innovation and data generation that can positively impact clinical practice and potentially differentiate our medicines
  • An ‘End to End’ approach to evidence, in particular an evaluation of the place/need for Real World Evidence (RWE) and incorporation of Patient Reported Outcome (PRO) strategies
  • Drive an external engagement strategy, pulling through elements of diversity and inclusion
  • Build external collaborations (e.g. relationships with KEEs, investigators, scientific associations, digital therapeutics/diagnostics partners)
  • Seek and incorporate external advice (e.g. via advisory board meetings, 1:1 consultation)
  • Anticipate future trends and needs in the marketplace
  • Input into commercial forecasts and scenarios, identifying trends and opportunities
  • Pricing and reimbursement considerations
  • Market engagement

Internal Contacts

  • Early project team (e.g. development, commercial, regulatory, publications, PRO-scientists, patient centricity, digital)
  • Medical and Payer Evidence
  • Insights and Analytics
  • External Scientific Engagement team
  • Brand Heads and GMALs (in-line brands)
  • Market Access and Pricing
  • Competitor Intelligence
  • Market and Regional Medical Leads

External Contacts/Customers

  • KEEs and investigators
  • Research organisations
  • Medical and scientific societies
  • Medical education groups

Budget responsibility

  • Ensures effective management of assigned budget for defined activities

Education, Experience, Skills and Abilities 

·Medical/clinical expertise in CVRM (>3 years), scientifically strong; doctoral-level education (MD, PharmD or PhD) preferred

  • Experience and/or appreciation of clinical development, incl. study design and execution, regulatory interactions
  • Experience and/or appreciation of commercial model, incl. life cycle management
  • Track record of leading the implementation of large scale, impactful medical/clinical initiatives
  • Experience working at a global/international level, with appreciation of local market dynamics
  • In depth understanding of the Medical Affairs space (current and evolving), able to apply insights to inform discussions around trends, risks, and opportunities
  • Demonstrable broad network of experts/supporters, built via an ability to form strong alliances
  • Innate ability to work successfully in a fluid matrix environment
  • Strategic, innovative thinker
  • Enterprise leader
  • Analytical mind-set, quickly able to assess large amounts of information and distill into key messages and actions
  • Persuasive and articulate communicator who can sell ideas to others
  • Ability to develop and deliver executive presentations
  • Experience effectively managing multiple stakeholders at all levels in the organisation
  • Comfortable challenging the status quo
  • Exceptional collaborator
  • Self-starter, able to manage multiple projects under pressure to tight timelines
  • Can bring value and can fluidly flex between high level strategy discussions and the details of execution
  • Integrity and high ethical standards


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

10000960 G MAGE BioPharmaceuticals

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.