Senior Scientist, Targeted Tumor Delivery
What is Happening at AstraZeneca
At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.
We are seeking a highly motivated Senior Scientist in Targeted Tumor Delivery with deep scientific and technical expertise in antibody therapeutics with a track record of scientific excellence to join our team in Waltham, MA USA. As a Scientist in our Oncology R&D department you will be a key member of a team focused on supporting oncology projects through the drug discovery and development process. You will bring your theoretical and practical expertise in cancer biology to establish assay systems and deliver datasets that will have direct impact on targeted therapeutics.
AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused on bringing novel concepts in immuno-oncology to unmet medical need.
Our Waltham, MA facility builds life-changing medicines for people around the world. The modern, vibrant scientific campus employs more than 800 experts in our field, and it is only a short drive from Boston, MA. It is filled with cutting edge technology. Our work areas were built to facilitate teamwork, interaction and cross functional science. We believe employees benefit from being challenged and inspired at work.
The Boston R&D site located in Waltham, MA is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space. Site amenities include:
- Modern 64-acre campus nestled in 200+ acres of nature conservation land & hiking trails
- Flexible, agile lab design with co-located write-up space
- Vibrant site community with activities, clubs, sports & games
- Onsite business & meeting center, office, AV & catering support
- Onsite outdoor activities (e.g. frisbee golf, garden club, volleyball, etc.)
The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region. It’s home to more than 800 scientists and experts working in nine different pharmaceutical and biotech companies. The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients.
It is a great place to work in the heart of one of the world’s most vibrant research cities.
What Does This Role Involve?
- Working in this laboratory-based position within the Oncology Research group you will develop, design, conduct and analyze in vitro and in vivo routine drug discovery research experiments independently. You will be responsible for communicating the results to team members and leadership groups. You will also review emerging literature and internal data to identify and credential new targets and contribute to target validation activities.
- You will also review emerging literature and internal data to identify and credential new targets and contribute to target validation activities.
- As a highly organized, self-motivated individual with a strong laboratory science background you will stay up to date with relevant technical and intellectual scientific expertise in antibody therapeutics, cancer biology & tumor immunology and have a genuine passion for this field of research.
Essential Skills and Capabilities
- Advanced degree (Master’s or PhD) with a focus on cancer biology, pharmacology and/or immunology
Experience & Skills
- A strong foundation in antibody therapeutics (preferably antibody-drug conjugates) and in-depth expertise in techniques for assessing their pharmacodynamic properties in biological systems
- Experience working with oncology models (e.g. human and murine cancer cell lines)
- Experience with multi-spectral flow cytometry and visualizing high content multi-parameter flow data
- Molecular biology and biochemistry skills (e.g. qPCR, western blotting, ELISA)
- Genetic modification of cell lines and/or primary cells (e.g. shRNA, CRISPR)
- Cellular imaging techniques
- Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment
Desirable for the role
- PhD with cancer biology, pharmacology, immunology or immuno-oncology focus is preferred
- A foundation in immunology / immuno-oncology, and expertise in techniques for the analysis of immune function and phenotype
- Experience with a range of in vitro skills for analysis of human immune cell function
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.