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Director of DMPK (Oncology)

Location Waltham, Massachusetts, United States Job ID R-183929 Date posted 09/04/2024

Director of DMPK (Oncology)

Waltham, MA

Description:

AstraZeneca is a global biopharmaceutical company driven by what science can do. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. Oncology R&D is a major focus area and growth platform at AstraZeneca. Our vision is to be at the forefront of developing the new generation of cancer therapies. We work together across all boundaries to have a positive impact in the world by solving complicated problems.  The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/DMPK, as well as translational PKPD Modeling & Simulation support to our portfolio.  We are looking for an individual who has a passion for ADME and DMPK science, applied to Cancer biology.

As the Director of DMPK, you will report to the Head of Boston DMPK and supervise ADME scientists locally in Boston who provide drug discovery and development support for our diverse portfolio including; small molecules, biologics, nano-medicines and PROTACs. The qualified candidate will also work closely with our ADME team in Cambridge (UK).  In addition, the selected individual will also function as a DMPK Representative/Design Lead Scientist and have the opportunity to provide input into drug discovery and development across the global Oncology portfolio.

The role holder will contribute to Oncology DMPK by:

  • Supervising and managing a team of ADME scientists by mentoring and challenging them, as well as providing expert advice and context for the interpretation of complex data.
  • Developing and implementing state-of-the-art technologies in the field of drug metabolism and transporters.
  • Leading DMPK-related compound design activities to ensure project ADME challenges are thoroughly assessed and resolved from HTS work-up to candidate nomination through risk mitigation and/or structural modification.
  • Applying an expert understanding of DMPK, physico-chemical property assays and/or biotransformation reactions to discovery project chemistry and data.
  • Recommending, initiating, leading and championing new innovations from external, global and local DMPK project science strategies that ensure cutting-edge science is applied to drug project issues.
  • Carrying out collaborative research aligned to DMPK and Oncology objectives and publishing research papers and reviews in internationally recognized journals.
  • Bringing a fresh perspective into the group and the enthusiasm to tackle new challenges and learn new skills.
  • Supporting the department’s leadership team in both the strategic vision for the department and in the efficient and progressive running of the department.
  • Managing student and Post Doc programmes.
  • Involvement in external collaborative projects with academic or cross-pharma pre-competitive groups.

Minimum Requirements:

  • PhD or equivalent degree in Pharmaceutical Sciences, Molecular Biology, Chemistry, Biochemistry or Pharmacology with experience in drug discovery, or a higher degree in a research area relevant to DMPK science.
  • At least 8+ years of relevant industry experience in ADME/Project Representation or a MS degree with at least 13+ years of relevant industry experience.
  • Strong technical knowledge of DMPK science with a proven ability to delineate the impact of chemical structure on measured properties.
  • Practical experience of DMPK assay delivery including experimentation, assessment of assay quality and troubleshooting of data issues.
  • Track record of successful problem solving, high quality science and influencing of stakeholders, particularly in a drug project context.
  • Excellent interpersonal skills that lead to successful collaborative working relationships.
  • Good understanding of the drug discovery process and how DMPK studies contribute to that process
  • Desire to carry out scientific development and research work with a view to publishing collaboratively
  • Can-do attitude and a desire to learn and adapt is essential.
  • Experience and knowledge of working with multiple modalities including; small molecules, biologics, nano-medicines and PROTACs is a plus.

About The Site

The Waltham R&D site is home to our small-molecule oncology research in North America, and is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space.

The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region. It is home to more than 800 scientists and experts working in nine different pharmaceutical and biotech companies. The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients. Plenty of free parking, with charging stations now available for electric vehicles, and shuttle service to local transportation hubs.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

10001091 F SCDP

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