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ADME Scientist, DMPK (Early Oncology R&D)

Location Waltham, Massachusetts, United States Job ID R-121572 Date posted 13/10/2021

ADME Scientist, DMPK (Oncology)

The Oncology Drug Metabolism and Pharmacokinetics department

Location: Waltham, US

Do you have expertise in Oncology, and a passion for PKPD modeling and DMPK science, applied to Cancer biology?

Would you like to apply your expertise to impact the lives of patients in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca is the organisation where you can make that happen!

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take calculated risks that write the next chapter for our pipeline and Oncology team.

Oncology R&D is a major focus area and growth platform at AstraZeneca. Our vision is to be at the forefront of developing the new generation of cancer therapies. We work together across all boundaries to have a positive impact in the world by solving complicated problems.

About The Site

The Waltham R&D site is home to our small-molecule oncology research in North America, and is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space.

The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region. It is home to more than 800 scientists and experts working in nine different pharmaceutical and biotech companies. The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients. Plenty of free parking, with charging stations now available for electric vehicles, and shuttle service to local transportation hubs.

Business Area

Be part of fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our innovative pipeline. We deliver this value through launch excellence, commercial effectiveness and maximising the lifecycle. By leveraging our commercialised portfolio we are confident we can change the practice of medicine and redefine cancer treatment.

Oncology R&D is a major focus area and growth platform at AstraZeneca. Our vision is to be at the forefront of developing the new generation of cancer therapies. The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/DMPK, as well as translational PKPD Modeling & Simulation support to our portfolio. We work together across all boundaries to have a positive impact in the world by solving complicated problems.

Our team is growing, and we have an opportunity as a Senior Scientist that will play a pivotal role in helping us to direct our capabilities toward improving patients’ lives.

The Oncology Drug Metabolism and Pharmacokinetics department provides ADME/DMPK, as well as translational PKPD modeling & simulation support to our portfolio.  We are looking for an individual who has a passion for ADME and DMPK science, applied to Cancer biology.

As an ADME scientist, you will provide drug discovery and development support for our diverse portfolio including; small molecules, biologics, ADCs, nano-medicines and PROTACs. The qualified candidate will work closely with our established ADME teams in Boston (US) and Cambridge (UK) to analyze and interpret data which will be presented in a multidisciplinary team environment.

The role holder will contribute to ADME/DMPK by:

  • Independently designing and executing studies, analysing and interpreting data, and presenting findings back to project teams.
  • Developing and implementing state-of-the-art technologies in the field of drug metabolism.
  • Supporting the department’s leadership team in both the strategic vision for the department and in the efficient and progressive running of the department.
  • Providing disciplinary scientific leadership and presenting work through patents, publications and lectures.
  • Potentially functioning as a project team representative.

Minimum Requirements:

  • PhD or equivalent degree in pharmaceutical sciences, molecular biology or related discipline.
  • At least 3+ years of relevant hands-on industry experience in ADME or a MS degree with at least 7+ years of relevant industry experience.
  • Ability to conduct cell culture experiments and work with primary cells.
  • Experience investigating the fate of molecules in the beyond rule-of-5 property space is highly desirable.
  • Knowledge of bioanalysis within ADME/DMPK.
  • Trouble-shooting skills for assays and instrumentation.
  • Excellent interpersonal and communication skills.

Does this describe you? Do you want to be part of something ground-breaking? If so, don't hesitate in submitting that application today by clicking on the link below...alternatively, if you know of someone whose skills would suit this position, please alert them of this fantastic opportunity.

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

In addition to our passion for the discovery of innovative new medicines, we understand the importance of flexibility in our work-life environment, and we offer a wide variety of benefits, services and programs that provide our employees the resources they need to pursue not only their work goals but also their life goals. We are building a strong research teams that embraces the diversity of talents of team members and allow the larger group to grow and learn together to accomplish our collective goal to improve human health.

So, what’s next?

If you are already imagining yourself joining our team. Good, because we can’t wait to hear from you!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience, alternatively - If you know someone who would be inspired by this possibility, please share this posting with them.

Competitive salary and benefits package on offer.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

Closing date: 19th November 2021

Where can I find out more?

Connect with our recruiter - Sam Hunter -via LinkedIn on: a confidential discussion to explore how this role could be your next career move

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056721 E SCDP R&D Oncology (Susan Galbraith (07016555)) (85008610)

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.