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Scientist II / Senior Scientist

Location San Francisco, California, United States South San Francisco, California, United States Job ID R-062883 Date posted 10/09/2019

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.  We lead our industry in our development of a strong and varied pipeline. This means our people are here to win, we give you a breadth of opportunities to be curious and do cutting edge, unique work that has big impact on science and medicine.

Position Summary:

The Scientist II or Senior Scientist of Clinical Pharmacology and Safety Sciences will lead the design and execution of pharmacodynamic biomarker strategy using molecular approaches to support biologic drug development across multiple therapeutic area and developmental stages. Other responsibilities include development, validation and bioanalysis for the drug concentration of oligonucleotide modalities in preclinical and clinical studies. Being highly motivated with strong molecular biology skills and drug development experience will help to make you successful in this role.

Major Duties and Responsibilities:

·Serve as a bioanalytical function lead at across function project teams

·Lead the design and execution of pharmacodynamics biomarker strategy for preclinical and clinical studies using molecular approaches

·Oversee the development, validation and bioanalysis of pre-clinical or clinical samples for the determination of oligonucleotide drug modalities

·Supervise staff and prioritize resources to provide support for multiple projects

·Present results at internal and external meetings.

Requirements/Qualifications:

Scientist II requirements:   

  • PhD in biological sciences or related field with a minimum of 3 years of experience
  • Master’s Degree in biological science or related field with a minimum of 10 years of experience
  • Bachelor’s Degree in biological science or related field with a minimum of 13 years of experience

Senior Scientist requirements: 

  • Ph.D. in biology or related discipline with 7-10 years in industry

Special Skills/Abilities:

·Strong expertise in molecular biology and assay development

·Knowledge in drug development

·Demonstrated ability for scientific insight and conceptual thinking in development of strategic drug development programs

·Experiences in method development for molecular-based pharmacodynamic biomarkers and/or drug concentration for oligonucleotide drug modalities supporting preclinical and clinical studies

·Management experience to independently manage a team of scientists

·Excellent interpersonal, organization and communication skills

·Ability to work in a team environment and to deliver on multiple projects simultaneously

·Familiarity with assay validation guidelines and GLP regulations is a plus

·Proficiency with spreadsheet, word processing, and graphical computer programs (MS EXCEL, MS WORD, Graphpad Prism, for example) required

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.