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Senior Scientist - Genome Analytics

Location Royston, England, United Kingdom Job ID R-124534 Date posted 23/12/2021

Senior Scientist – Genome Analytics

Cambridge, UK

Competitive Salary + Benefits

Make a more meaningful impact to patients’ lives around the globe

Here you’ll have the chance to create a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most sophisticated diseases.

Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem. With our ground-breaking pipeline, the outlook is forward-thinking.

Be proud to be part of a place that has achieved so much, yet is still moving forward.

Our inquisitive culture is uniquely open and collaborative. Here, you’ll be surrounded by curious minds from a diverse set of backgrounds who think differently about the world.

AstraZeneca is a science-led, global biopharmaceutical company, with a focused portfolio in core therapies. We are committed to improving the health and lives of people across the globe, through our research and development platform, and a growing late-stage pipeline.

Working in over 100 countries, we have strength in emerging markets, and our medicines are used by millions of patients and clinicians worldwide. Working here means collaborative and results driven to make the impossible a reality.

Our Centre for Genomics Research (CGR) has an exciting opportunity for a Senior Scientist – Genome Analytics to contribute to its Genomic Initiative.

The Genomic Initiative includes the sequencing of participants from AstraZeneca clinical studies as well as large population cohorts.

For example, exome and genome sequencing data as well as metabolomics, proteomics and sophisticated phenotypic data, are available from up to 500,000 UK Biobank participants.

What’ll I do?

This role is an opportunity to be part of ground-breaking research at the forefront of human genomics.

This role will focus on the development of innovative and robust statistical methods to analyse large-scale human genomics datasets, and/or on the application of such methods and interpretation and communication of results.

You will be part of a dynamic team in CGR’s multidisciplinary genomics research environment comprising bioinformaticians, computational biologists, genome scientists, software engineers, postdoctoral researchers, disease area specialists.

You will also work closely with specialists in translational science, drug discovery, pre-clinical modelling, and clinical development.

  • Lead and carry out quantitative genomic analyses on large-scale cohort studies, to identify risk and response associations for diseases of interest

  • Deliver novel insights into the biology of disease, validation of new targets for medicines and the improvement of selection of patients for clinical trials

  • Incorporate additional molecular data into genomic analyses such as gene expression data, metabolomics and/or proteomics

  • Work with sophisticated phenotype data (e.g., electronic health records and clinical trials) to better identify population subgroups of greatest interest

  • Develop analytical algorithms and tools to address scientific questions with big data

  • Contribute to publication of results

  • Support and supervise more junior team members

  • Ensure all work is follows Good Laboratory Practice, Safety, Health and Environment standards and all internal AstraZeneca standards and external regulations

Crucial Criteria

  • Doctoral degree (or equivalent experience) in bioinformatics, biostatistics, complex trait genetics, computational biology, statistical genetics or a related field

  • Have experience in large-scale genetic data analysis, applied statistics, and/or machine learning

  • Coding skills appropriate for large scale genomics analysis

  • Understanding or curiosity about the potential of genomics to impact drug discovery

  • Possess superb communication skills and willingness to work within a team in a quickly evolving environment

  • Have a track record of peer-reviewed publications in high-level scientific journals

Desirable Criteria

  • Experience in analysing genome sequencing data

  • Experience in case-control sequencing based statistical analyses

  • Familiarity with high performance and/or cloud computing

  • Experience curating and analysing electronic health data

  • Experience quantifying and interpreting the clinical relevance of rare variants

Why we love it

If your passion is science and you want to be part of a team that makes a bigger impact on patients’ lives, then there’s no better place to be. Here we truly understand science and apply it every day to strengthen and grow our pipeline.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

10001248 D DAIN R&D BioPharmaceuticals

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.