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Senior Director, Computational Pathology, Translational Science

Location Munich, Bavaria, Germany Job ID R-161333 Date posted 12/03/2023

In the role you will Lead a group of scientists and physicians that will work to support programs directly, championing a culture of engagement, respect, and high performance. Provide leadership, coaching and mentoring.

Work with Computational Pathology Medicine leadership teams along with program leaders to generate the translational vision for each project; how it will benefit a specific patient population and ensure that CPM generates data vital to demonstrate potential to bring a differentiated and impactful treatment solution to that patient population. Leverage dependable CRO’s and your network of academic collaborators to bring high quality science, enabling data driven decisions. Ensuring a generation of robust and high-quality patents and regulatory documentation in support of molecules progressing through pre-IND and clinical development. Authorship of peer reviewed manuscripts and presentation of original work at scientific conferences and symposia; Active presentation of findings at internal and external meetings


AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.


Our Computational Pathology site in Munich is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels able to be themselves is at the core of AstraZeneca’s priorities, it’s vital to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you: events, lunch & learns, comfortable environment, balanced office working environment, events, childcare support and of course the Alps around the corner for hiking, biking and skiing.


From diagnosis to later stage development, we’re focused on leading the way forward to create solutions that transform lives. We are focused on identifying and treating patients earlier, where there is greater curative potential. With the greatest number of early stage cancer trials in the industry, we are getting closer to finding cures every day. It is the breadth and strength of our innovative pipeline that offers both security and stability.

What you’ll do

  • Provide high quality scientific and translational leadership to building CPM translational science team, balancing resource and capability needs for new and ongoing projects to enable successful and timely progress to clinical evaluation in selected patient populations.

  • Participate with technical and strategic expertise as a member of cross functional project teams in the design, validation and construction of training and validation of data to develop computational pathology capabilities and applications.

  • Collaborate with high-functioning multidisciplinary teams to analyze and interpret data, especially in context with other clinical data and drive the multimodal integration of CP data with other data sources

  • Support software development teams in the development of image/data analysis solutions and products, the digital pathology portal platform through active participation in the testing of these tools and technology

  • Conceive and execute translational strategies to support advancing discovery projects into clinical development programs, providing the link between early research and the clinical team.

  • Oversee the development of detailed work plans to incorporate quantitative, objective end points into clinical studies to demonstrate target engagement, pharmacodynamic regulation of pathways of interest, modulation of pharmacologic mechanism and information to aid patient selection

  • Work with other matrix functional areas to define key aspects of the integrated development plans, including key early clinical translational steps in the development strategy, the assessment of medical need, proposal of clinical development pathways, review of preclinical data for clinical implications and acquisition of clinical samples.

  • Identify, establish, and manage an external network of partners/collaborators to access and develop required assays, models, and capabilities at the right time to fully enable project plans, including managing collaborations and internal capabilities for accessing and analysing patient tissue samples.

  • Work with other matrix functional areas to develop and implement Computational Pathology specific assay development and standard approaches.

  • Contribute to writing and reviewing reports and documents related to the regulatory process including IND submissions and to meetings with regulatory bodies

Essential for the role

  • Advanced degree (MD or PhD) in translational science/medicine, Immunology, Immuno-oncology or related field and extensive industrial experience

  • Deep knowledge and understanding of oncology, clinical trial methodology and regulatory requirements including companion diagnostics; precision oncology drug development paradigms, clinical pharmacology, and technical, business, and regulatory approaches

  • Demonstrated track record in leading cross-functional teams and work streams in an international matrix environment (e.g., translational medicine, biostatistics, regulatory, pre-clinical pharmacology, clinical and immunogenicity assay development)

  • Experience in machine learning, and artificial intelligence as applied to digital pathology research or practice required

  • Experience in applying digital tissue analysis techniques for immuno-histochemistry, multiplex immuno-fluorescence, and/or spatial-omics approaches

  • Understanding of the entire therapeutic development process, including clinical and non-clinical study design, assay development and importance of target product profiles with key determinants of investment decisions.

  • Experienced at managing external collaborations/partnerships, as well as mentoring teams/individual scientists in the achievement of project goals

  • Demonstrable track record of successful research supported by publications (peer reviewed publications, oral presentations, posters & patent filings)

  • Strong leadership and oral/written communication skills, interpersonal skills, and ability to multi-task a dynamic portfolio of drug projects and a robust technology development capability.

  • Strong publication record and proven communication and presentation skills to wide audience (specialists and non-specialists).

  • Excellent problem-solving skills with clear understanding of the balance of innovation, smart risks, fit-for-purpose solutions, and timely project delivery

  • Ability to drive, influence, manage, execute, and deliver results for complex multi-functional, interdisciplinary, and international projects.

  • Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca.

Competitive salary package and benefits

Close Date: 10/04/2023

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients, and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth, and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already considering joining the team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it’s yours.

  • If you’re curious to know more please reach out to Louise Bennett

Where can I find out more?

Our Social Media,

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.