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Senior Manager, Health Economics and Payer Evidence - Oncology

Location Mississauga, Ontario, Canada Job ID R-136017 Date posted 23/06/2022

AstraZeneca in Canada

Headquartered in Mississauga, Ontario, AstraZeneca has been recognized as a Greater Toronto Area Top Employer for eight straight years. We pride ourselves on creating a collaborative culture that champions knowledge-sharing, entrepreneurial thinking and innovation – ultimately providing employees with the opportunity to work across teams, functions and even the globe.

To best support our employees in balancing personal and work commitments, we’ve embraced a hybrid model of working that gives employees flexibility in how they manage their time. Our head office and BlueSky Hub in downtown Toronto are purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects.

Our commitment to sustainability is also central to our culture and part of what makes AstraZeneca a great place to work. We know the health of people, the planet and our business are interconnected which is why we’re taking bold action to tackle some of the biggest challenges of our time, from climate change to access to healthcare and disease prevention.

Our Position

Are you motivated by building forward-thinking health economic strategies to support health care decision-making and patient access? Do you want to apply your expertise in health economic evaluations, decision analytic modelling, cost-effectiveness analyses, and HTA in a fast-paced working environment with a team of multi-disciplinary experts?

We are looking for a Senior Manager, Health Economics and Payer Evidence (HEPE). In this position, you will use your strategic, analytical, and leadership skills to make a difference in the lives of Canadian patients.

This key role acts as the lead health economist on a diverse cross-functional team, who delivers strategic health economic models for the inline and future oncology portfolio at AstraZeneca. This includes designing key health economic dossiers for HTA submissions, exploring public health databases and working alongside Canadian researchers to generate payer evidence, and providing thought leadership for cross-functional teams so that patients can access our life-changing medicines.


  • Provides inspirational leadership and direction to the Health Economics team to deliver quality insights and evidence for market access strategies. This includes coaching and mentoring the team, managing performance discussions and attracting talent.

  • As the senior health economics lead, your role is to independently conceptualize and design economic models and identify appropriate data sources, including clinical trials, HRQoL studies, costing studies, SLRs and ITCs, retrospective database analyses, prospective clinician or patient epidemiological studies to support your modelling strategies.

  • You deliver high quality economic evidence (e.g. submission dossiers, cost-effectiveness & impact models and other supporting materials) to support submissions to HTA agencies and payers.

  • You support evidence gap analysis and, in collaboration with the Medical Evidence team, generate decision-grade real-world evidence (RWE) to demonstrate value to HTA reviewers, payers, and clinical decision-makers and also develop Canadian and global publication plans for this RWE.

  • With your expertise, you provide technical health economic and evidentiary advice to your cross-functional and leadership team members, and continue to build and maintain a network of external influencers (economists, clinicians, academics).

  • You develop a record of peer-reviewed publications and presentations, and are skilled at communicating and presenting at external conferences and payer/HTA meetings.

  • You will act as coach/mentor to colleagues and the HEPE team.

  • Collect and report Adverse Events in accordance with AstraZeneca policies andprocedures.


  • A Master’s degree, or equivalent, in a numerate subject (e.g. health economics, epidemiology, medical statistics, management science)

  • 5+ years of pharmaceutical or health-related experience in a role involving reimbursement-related activities or health policy, or similar government experience.

  • Experience in building health economic models (partitioned-survival analysis, Markov models, discrete event simulations), preferably for oncology products

  • Experience/knowledge of survival analysis and/or individual patient analysis (cohort studies), or network meta-analyses is desirable

  • Experience building other payer evidence SLRs, ITCs, NMAs, survival/statistical analyses, and budget impact models

  • Advanced research and analytical skills; ability to derive insights from large datasets as well as work with ambiguity and synthesize value-based recommendations based on small, incomplete datasets

  • Experience of previous HTA submissions to CADTH, INESSS, and private payers

Great People want to Work with us! Find out why:

Are you interested in working at AZ, apply today!

AstraZeneca is committed to taking every reasonable precaution to protect employees, our customers and the healthcare systems in the communities in which we serve. In an effort to protect the wellbeing of our employees and customers, full COVID-19 vaccination is an essential requirement of all positions at AstraZeneca. As such, all offers of employment will be conditional upon either (i) proof of full COVID-19 vaccination or (ii) proof of need for accommodation under relevant human rights legislation, and AstraZeneca’s determination that the requested accommodation can be provided without undue hardship.  You will be required to submit proof of full vaccination or proof of need for accommodation during our background screening process.

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

10000131 E CNMA BioPharmaceuticals

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.