Skip to main content
Search roles

Senior Scientist/Associate Principal Scientist – Early Product Development and Manufacturing

Location Macclesfield, England, United Kingdom Job ID R-110809 Date posted 10/06/2021

Senior Scientist/Associate Principal Scientist – Early Product Development and Manufacturing

Location: Macclesfield, UK

Salary & Benefits Competitive

Make a more meaningful impact to patients’ lives around the globe

Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

Join the team that follows the science unlike anywhere else. This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs.

Pharmaceutical Sciences is a department within AstraZeneca R&D unit. The vision for Pharmaceutical Sciences is to deliver the therapies of the future through scientific leadership in drug delivery, design of synthetic routes and manufacturing of Active Pharmaceutical Ingredients (API) and drug product. Our portfolio of projects includes traditional small molecules, nucleotide-based therapies and nanomedicines across AstraZeneca’s therapy areas.

An opportunity exists in Pharmaceutical Sciences for an exceptional individual in the area of solid-state chemistry/formulation, working across drug substance and drug product disciplines.  We are looking for an enthusiastic and highly capable Senior Scientist/Associate Principal Scientist to join our Early Product Development and Manufacturing (EPDM) team in either Macclesfield, UK.  You will work closely with analytical, formulation and biopharmaceutics scientists in EPDM as well as scientists in other functions to drive science and innovation within drug projects including global collaboration with scientists at our Macclesfield, Cambridge, Boston & Gothenburg sites.

The successful applicant will become a core member of the global Solid-state skill area which is responsible for ensuring suitable physical form and formulation screening, selection and control within drug substance and product. The team supports the full discovery and early development stages up to Phase II clinical trials. The successful candidate will be a self-starting, exceptional team player, committed to delivering high quality science to projects.


  • Responsible for ensuring suitable physical form and formulation screening, physical characterisation, form and formulation selection and control within drug substance and product.
  • Deliver robust physical forms and formulations which meet the needs of the patient.
  • Represent solid state skill area in projects and work closely with analytical, formulation, and biopharmaceutics scientists in EPDM as well as scientists in other functions to drive science and innovation.
  • Plan and conduct lab-based experimental work in accordance with project timelines.
  • Keep abreast with the scientific literature and proactively apply existing and novel approaches to projects.
  • Drive and lead science personally and within the department, manage external collaborations and publish novel work in peer reviewed journals.

Qualifications and Experience:

  • You will have a Chemistry or Pharmacy PhD or be a graduate with relevant experience in the area of solid-state chemistry, formulation, physical chemistry or related disciplines.
  • You will be a driven experimentalist, with a passion to deliver highly relevant knowledge to those around you.
  • You will have experience in the screening and characterisation of solids (e.g. X-ray diffraction, spectroscopy, thermal analysis, microscopic techniques, moisture sorption etc.), a good awareness of analytical methodology and an enthusiasm for laboratory-based work.
  • Experience in formulation of amorphous materials and various approaches such as spray-drying, hot melt extrusion etc.
  • Experience/knowledge or a keen interest in the field of automation, simulation or prediction would be advantageous.
  • Understanding of the principles and concepts of crystallisation.
  • Experience in amorphous materials and their characterisation will be advantageous as would experience in examination of crystal structures and use of relevant software tools e.g. tools such as Mercury, Materials Studio etc.
  • In depth understanding of how the physicochemical and solid-state properties of a drug, effect the manufacture, formulatability and in vitro and in vivo performance.

Skills and Capabilities:

  • Creativity and innovation, built on sound technical knowledge and problem-solving skills are required in order to deliver robust physical forms which meet the needs of the patient.
  • Assess, review and report data from own work, with a clear understanding of its reliability and interpret findings and draws authoritative conclusions and recommendations so that their significance can be appreciated. Present information for discussion in multi-disciplinary project teams.
  • Work as a member of cross-functional teams, with a large degree of independence representing own department or area of expertise.
  • You will have the ability to work flexibly, adapt to changing priorities, knowing when to deep dive into a problem and when to stop. You will have the ability to work both independently and as part of a team.
  • Ensure own work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Laboratory Practice (GLP).
  • Excellent communication, team working, networking and leadership skills & ability to lead and inspire colleagues.
  • Ability to work across departmental boundaries and influence others.
  • Ability to coach peers for enhanced individual and team performance.
  • Ability to manage complex portfolio of projects and/or a single project of high complexity.
  • Ability to drive and lead science personally and within the department and manage external collaborations.
  • Global mindset and ability to work across multiple geographical locations.
  • Role model for innovation.

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

So, what’s next?

Complete your application before the below closing date.

This role is open from 10/06/2021 and welcome with your application no later than 08/07/2021

Where can I find out more?

Follow AstraZeneca on LinkedIn

Follow AstraZeneca on Facebook

Follow AstraZeneca on Instagram

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056728 D SCPE R&D BioPharmaceuticals

We’ll keep you up to date

Sign up to be the first to receive job updates.

Interested InSearch for a category and select one from the list of suggestions. Search for a location and select one from the list of suggestions. Finally, click “Add” to create your job alert.

Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.