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Senior Research Scientist

Location Macclesfield, England, United Kingdom Job ID R-087899 Date posted 08/03/2020

HTS Senior Research Scientist

Alderley Park, Cheshire prior to relocation to Cambridge, England, United Kingdom

Salary: Competitive

At AstraZeneca, we’re not afraid to do things differently. We’re building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening up new ways to work, pioneering cutting edge methods and bringing unexpected teams together.

We are looking to recruit a Senior Research Scientist to join our Global High Throughput Screening (HTS) Centre in Alderley Park, prior to relocation to a new, state-of-the-art R&D centre in Cambridge. HTS is the only department within our world-leading pharmaceutical business that focuses unequivocally on Hit identification. This means you’ll get unrivalled exposure to the drug discovery process, working on multiple projects across therapeutic areas in a culture that fosters collaboration and open innovation – find out more at http://openinnovation.astrazeneca.com/

Our HTS Centre aids the definition of screening cascades in discovery programmes, uses cutting-edge assay technologies to generate high-quality screening data and delivers robust data packages to pursue tractable hit series. Whether you’re looking to share your experience, or get the training to build it, you could be part of a team that uses world-class science and technology to deliver the most innovative tools for drug discovery.

If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

Main Duties and Responsibilities

As a Senior Research Scientist in the HTS department you will join a team of scientists delivering High-throughput Screens to AstraZeneca drug projects and academic collaborators, enhancing the delivery of projects in compliance with SHE requirements. You will have a passion for scientific delivery and innovation, developing science and technology strategy and shaping the future of the HTS capability, and building trusted relationships with senior scientific colleagues.  You will be a member of the Discovery Sciences organization, working within a first-class scientific environment to support drug discovery across each of AstraZeneca’s Therapeutic Areas.  As part of an HTS team you will be key in delivering biology and technology output. We’ll also expect you to capitalise on publication and collaboration opportunities and to mentor less experienced scientists. You’ll have every tool to acquire both practical and academic skills and become a true expert in your field.

Within HTS at AstraZeneca we are looking to recruit people with demonstrable experience in cell imaging, biochemical or biophysical screening approaches or significant at scale data evaluation experience utilising robust statistics and use of specialised analysis and graphical software.

Essential Candidate Criteria

  • BSc/PhD in a relevant biology discipline
  • Flexibility to work at Alderley Park, Cheshire initially and then relocate to Cambridge
  • Demonstrable experience in one or more of: cellular; imaging; biochemical; biophysical screening approaches and an ability to troubleshoot screening problems
  • Ability to drive the practical application of new assay approaches to screening and drug discovery science in Hit Discovery
  • Familiarity with technology-rich lab environments.

Desirable Candidate Criteria

  • Strong understanding of the analysis and interpretation of screening data to understand mechanism of target engagement
  • Assay Development, cascade design and drug discovery project team experience
  • Experience of at scale data analysis and statistics
  • Understanding of state-of-the-art assay and automation technology platforms
  • Publication record and/or experience of presenting scientific data
  • Experience of applying high volume/complexity data generation methods to drug discovery projects
  • Experience of small molecule screening and/or fragment-based screening
  • Experience of laboratory automation and a keen interest to develop knowledge in this space
  • Experience of coordinating SHE activities

AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

How to Apply

If you are interested in applying for this role please click and apply on line, including your current CV.

Closing Date for Applications: midnight on 1st Sept 2020



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.