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Research Associate I, Analytical Development, Viral Vector Product Development

Location Lexington, Massachusetts, United States Job ID R-196224 Date posted 29/03/2024

This is what you will do:

This positionwill play a key role in Alexion’s Viral Vector Product Developmentanalytical development team, interacting with internal teams within the Genomic Medicine and Product Development Clinical Supply groups.The research associate will follow established standard operating procedures (SOPs) to perform molecular and biochemical based assays to characterize recombinant adeno-associated viral (rAAV) vectors and othergene editing modalities to support process development and testing of pre-clinical grade research products.

You will be responsible for: 

  • Performing analysis of rAAV vectors (qPCR, ddPCR, ELISA, automatedprotein and DNA electrophoresis)

  • Independently conducting assays for in-process and final products to determine viral vector product quality

  • Analyzing data and recording results in electronic lab notebook in a timely manner, writing reports, and communicating results to end users

  • Assisting with vector reference qualification and further development of existing assays for improved performance

  • Writing technical reports and delivering scientific presentations summarizing data

You will need to have:

  • BS in Cell Biology, Biochemistry, Molecular Biology or related scientific discipline

  • 0-2 years of relevant academic or industry experience 

  • Excellent attention to detail and accuracy in following protocols is necessary

  • Must have strong organizational and communication skills

  • Strong desire to learn multiple techniques and willingness to provide support as required

  • Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment

  • The duties of this role are generally conducted in an lab environment.  As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift 15pounds unassisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. 

We would prefer for you to have:

  • Experience testing AAV, viral vectors, or other types of biologics 

  • Experience with the performance of routine biological assays including qPCR, ddPCR, ELISA, SDS-PAGE, and agarose gel electrophoresis is desirable

  • The ability and desire to learn new techniques if needed

  • Candidates should be self-starters, comfortable with autonomy, and embrace opportunities to develop new genomic medicines as part of a dynamic team within Alexion.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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