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Senior Scientist, In Vitro Cardiovascular Biology

Location Gothenburg, Västra Götaland County, Sweden Job ID R-153304 Date posted 23/11/2022

Do you have expertise within in vitro cardiovascular biology and enjoy working in the lab? Would you like to apply your expertise in a global company that is accelerating innovative science and turn ideas into life changing medicines? Join us to discover future treatment of Cardiovascular, Renal and Metabolic diseases!

At AstraZeneca, we work at the cutting edge of science to develop the ground-breaking medicines of the future – here we do things that have never been done before. We put patients first and strive to meet their unmet needs worldwide.

CVRM is one of three main therapeutic research areas within AstraZeneca. Early CVRM has a patient-centric approach for discovering novel treatments for patients with cardiovascular-, chronic kidney- and metabolic disease and delivers candidate drugs into late-stage clinical development. In the Bioscience Cardiovascular department, we focus on identifying and validating new drug targets for treatment of patients with cardiovascular disease and heart failure, as well as evaluating pharmacological aspects, e.g. efficacy and mechanism of action, of potential new drug candidates. The in vitro team delivers key data to projects across all phases of the drug discovery and development process, and we work with different modalities such as small molecules, modified mRNA, antibodies, cell therapy, antisense oligonucleotides and peptides.

We are now recruiting a SeniorScientist with expertise in cardiovascular biology to join the Bioscience Cardiovascular in vitro team within the Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca in Gothenburg, Sweden.

What you’ll do

As a Senior Scientist, you will play a key role in driving science and projects within the cardiovascular area forward. This is a lab based role where you will explore novel drug targets with key in vitro data. Collaboration is critical for successful delivery of drug projects and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. You will work with in vitro biology using cell lines, pluripotent stem cells (PSC) and primary cardiovascular cells along with molecular and functional biology techniques. You will have the opportunity to try novel techniques and ideas required for progressing existing portfolio and novel science. Responsibilities include:

  • Independently design, develop and run in vitro studies and assays for target identification and validation  

  • Work with molecular biology methods, imaging and assays for functional readouts such as contractility and cardiac metabolism

  • Contribute to communications of scientific findings through publications in scientific journals and at meetings

  • Proactively contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared

Essential for the role

  • PhD or master’s degree in biology, pharmacology, cardiovascular disease or similar

  • Strong experience in cell and molecular biology, biochemistry and relevant in vitro/ex vivo assays within the cardiovascular area

  • Experience in handling and manipulating relevant PSC cells and primary human and animal cardiac cell types, including cardiomyocytes

  • Excellent English communication skills, both spoken and in writing

Desirable for the role

  • Experience with cardiomyocyte biology and function in healthy and diseased systems

  • Background in drug discovery and development in the pharmaceutical industry

So, what’s next?

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!

For more information about the position please contact Erik Ryberg through +46-31-7761000.

Welcome with your application no later than December 15, 2022

Where can I find out more?

Global Gothenburg: https://www.astrazeneca.se/om-oss/verksamheten-i-sverige/goteborg/relocate-to-gothenburg.html

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Life in Gothenburg: https://www.movetogothenburg.com/

Why AstraZeneca?

Our Gothenburg site is one of AstraZeneca's three strategic R&D centers. With more than 2,400 employees from over than 50 countries, our vibrant Gothenburg site is a truly inspiring place to work. Here, the history and future of scientific breakthrough come together. We believe that the diversity of our people is crucial to bringing new discoveries to life.

You will be offered a competitive salary and excellent benefits, such as extra paid Holiday, Private Medical Benefits, On-site exercise and much, much more.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.