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Senior Scientist – Biocatalysis

Location Gothenburg, Västra Götaland County, Sweden Job ID R-196317 Date posted 01/04/2024

AstraZeneca is a global, science-driven biopharmaceutical company dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality.

We push the boundaries of science to deliver life-changing medicines.

Pharmaceutical Sciences is a function within the AstraZeneca’s Biopharmaceuticals R&D unit that works across all aspects of CMC development to ensure implementation of intelligent design of medicines and delivery systems to the early portfolio. The function has four departments: Early Chemical Development, Advanced Drug Delivery, Early Product Development and Manufacturing, and Data Science and Modelling.

Early Chemical Development (ECD) is a World-Class CMC department with responsibility for early phase Drug Substance Manufacturing. The department’s responsibilities span from early engagement with Discovery Chemistry groups up to manufacturing of Phase II Clinical material, and its key skill areas include Analytical Chemistry, Crystallisation, Isotope Chemistry, Large-Scale Laboratory (Kilo-Lab) Manufacturing, Process Chemistry, Process Design, Process Engineering, Route Design and Separation Science.

In Early Chemical Development, an exciting opportunity has arisen for a Senior Scientist – Biocatalysis to support the investigation and implementation of enzymatic steps within the Route Design activities based at our Gothenburg site.

You will be a key member of the team with the task to identify and validate opportunities in the early project portfolio by performing screening of enzymes towards desired biocatalytic reactions and implement reactions at scale to enable manufacturing for preclinical studies.

You will bring a strong understanding of biocatalysis to the design and development of robust enzymatic manufacturing steps. This role will work cross-functionally with internal and external partners and with medicinal chemists, process chemist colleagues, and the broader biocatalysis and enzyme engineering team.

The role is primarily laboratory based and will involve working flexibly across laboratories and our Large-Scale Laboratory (up to 100 litres) for non-GMP manufacture of drug substance. This will also involve advising our development teams and our Contract Development and Manufacturing Organisations (CDMOs).

ECD is committed to personal development and as such ensures that every individual has opportunities to grow within the business towards more senior roles.

Typical Accountabilities

The role will be primarily lab based, focused on developing steps for up to 5 kg manufactures.

The candidate will have the following accountabilities:

  • Develops and delivers enzymatic steps for drug substance manufacturing at 0.1 to 5 kg scale according to project timelines.
  • Contributes to larger scale enzymatic syntheses in collaboration with process chemist colleagues.
  • Works with discovery chemistry colleagues to define and evaluate opportunities according to project priority.
  • Responsible for tech transfer to external CMOs and CROs for biocatalytic step investigation, implementation and delivery of manufacturing campaigns
  • Assesses, reviews and reports data from own work, with a clear understanding of its reliability, interprets findings and draws authoritative conclusions and recommendations so that their significance can be appreciated
  • Maintains up-to-date knowledge of technical advances in biocatalysis, identifying potential benefits for the business
  • Grows relationships with internal and external partners towards technological and scientific developments. Ensures pioneering technology is applied, delivering new ways of working to improve project delivery and driving innovation
  • Presents information for discussion at project teams and across other functions
  • May work as a member of cross-functional teams, with a large degree of independence representing own department or area of expertise
  • Ensures own work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards

Education, Qualifications, Skills and Experience

Essential

  • Ph. D. degree or equivalent experience in a relevant field or BSc/MSc or equivalent experience with relevant industrial experience to an equivalent level
  • Recent practical experience in the area of biocatalytic chemistry.
  • Ability to plan, prioritize and perform work independently, including problem-solving and seeing opportunities
  • Understanding of the principles and concepts in pharmaceutical science
  • Good understanding of the R&D operating model and the contribution Pharmaceutical Development makes to development and launch of new medicines
  • Excellent English both spoken and written

Desirable

  • Experience scaling up (bio)catalytic reactions to multi-gram and higher, including downstream processing and product isolation
  • Experience in discovery and the early development phases of the drug development process
  • Experience of High-Throughput Experimentation in organic synthesis, either in traditional chemistry or in biocatalytic transformations
  • Experience in bacterial transformation and flask-based enzyme production
  • An interest in analytical science to develop and run UPLC and SFC analysis
  • Understanding of patent and IP issues

Specialist and functional area expertise, specifically in the following skills:

  • Biocatalysis
  • Synthetic organic chemistry
  • Analytical chemistry and assay development: proficient with MS, NMR and other analytical techniques needed to evaluate enzyme performance

Why AstraZeneca

At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next? We welcome your application no later than April 17th, 2024.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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