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Molecular Biomarker Lead

Location Gothenburg, Västra Götaland County, Sweden Gaithersburg, Maryland, United States Job ID R-153301 Date posted 23/11/2022

Make a more meaningful impact to patients’ lives around the globe

Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.

Join the team that follows the science unlike anywhere else. This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs.

Our Early R&I Translational Science and Experimental Medicine (TSEM) department is an agile environment with a science focused culture. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population and close the gap between bench science and bedside clinical practice.

One of our key remits is the development of biomarkers to drive patient segmentation, demonstrate target engagement, guide dose selection and bridge to clinical outcome. As a molecular Biomarker Scientist you are accountable for discovery of respiratory and immunologic disease precision and target engagement biomarkers and their development and validation specifically, but not limited to, the fields of transcriptomics and proteomics.

Skills:

  • Broad understanding of opportunities and limitations of NGS (next-generation sequencing technologies technologies) in the context of biomarker discovery.

  • Expertise in Immunoassay development and validation

  • Experience and understanding of manipulation of DNA and RNA to create custom assays fit for biomarker discovery.

  • Experience in setting up novel molecular biology techniques.

  • Be responsible for design, execution, interpretation and reporting of molecular based biomarker studies.

  • Be providing and serve as an expert in the development and deployment of novel molecular based biomarker platform technologies to enable the respiratory biomarker discovery platform.

  • Invent and discover novel biomarkers through bioinformatic analysis of omics datasets.

  • Dedicatedly exploit available omics-initiatives.

  • Validate knowledge extracted from big omics-datasets through robust biomarker analysis in human tissue.

  • Use experimental medicine (MeMo studies) to identify and validate biomarkers and support recall by genotype clinical study designs.

  • Drive innovation in Biomarker Discovery through internal scientific development and external collaborations.

  • Make AZ scientifically visible by publishing scientific papers and presenting data at conferences.

Essential Requirements:

This is a role that requires a strong scientific background as well as excellent technical skills. You need outstanding team working skills and a history of successful collaborations. Furthermore, you are expected to have a deep understanding of the drug discovery and development process from lead identification through clinical trials.

  • PhD within relevant field.

  • Track record of delivering state-of-the-art biomarkers to projects in discovery and/or development setting.

  • Familiar with biomarker invention and implementation.

  • Proven experimental drive and background in basic science related to respiratory research.

  • Technical expertise in specific biomarker discovery and analysis platform including genomics, transcriptomics, proteomics, metabolomics, epigenomics, lipidomics, NGS, mass spec etc.

  • Experience and knowledge of the biological basis for patient segmentation.

  • Good networking and interpersonal skills.

  • Strong publication record.

  • Understanding of relevant technologies and methods along with scientific laboratory skills.

Desirable Requirements:

  • Post-doc experience in a relevant field

  • Experience in pharmaceutical R&D

  • Experience and deep understanding of respiratory and immunological disease biology including understanding of molecular pathways and mechanisms.

Why AstraZeneca


At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.


So, what’s next!


If this sounds like an exciting career opportunity - apply today!

We look forward to getting to know you better and welcome your application. Advertising opens on 24th Nov and closes on 8th Nov 2022.

Where can I find out more?

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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Glassdoor logo Rated four stars on Glassdoor

Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.