Associate Principal Scientist – ADME therapeutic oligonucleotides

Are you an in vitro DMPK scientist with expertise in Absorption, Distribution, Metabolism and Elimination (ADME), from small molecules to oligonucleotides? If so, we invite you to join our team at AstraZeneca, where we are committed to turning innovative science into life-changing medicines. We are currently recruiting a scientist to strengthen capabilities in the therapeutic oligonucleotides area within the Drug, Metabolism and Pharmacokinetics (DMPK) department. This is your chance to contribute to the discovery of new treatments for Cardiovascular, Renal and Metabolic diseases!

Accountabilities:
As a senior in vitro ADME scientist, you will be part of a team at the forefront of DMPK science. You will be responsible for designing, conducting, interpreting, and reporting of in vitro ADME studies for drug discovery and development projects. In your role, you identify improvements in technologies that can be successfully applied to a highly competitive drug discovery or development paradigm that contributes to achievement of short and long term business goals and influences strategic direction. You will also serve as an ADME lead for oligonucleotide therapeutics projects, identifying issues and working collaboratively to resolve them. Additionally, you will provide scientific leadership by leading collaborations with key academic centres and presenting work through lectures and publications.

Essential Skills/Experience:

• PhD or equivalent background in Pharmacy, Biology, Biochemistry, Medical Biosciences or a similar discipline, with at least three years of experience relevant to the position

• Versatile in in-vitro laboratory skills e.g. handling and culturing of primary human hepatocytes and other human cells and tissues, 3D-cultures, molecular biology methods and image analysis, enzyme and transporter kinetic studies

• Broad knowledge about ADME processes and relevant in-vitro models of drug disposition

• Excellent understanding of design and interpretation of in-vitro studies with oligonucleotide drugs 

• Scientific leadership, evidenced by a publication track record 

• Excellent interpersonal skills and good communication skills in English, both verbal and in writing

• Strong ability to engage and collaborate across boundaries with a problem-solving attitude and focus on delivery 

Desirable Skills/Experience:

• Experience from industry environment

• Knowledge in omics technologies and bioinformatics

• Experience in bioanalytical techniques, e.g. LC-MS 

• Expertise in automation equipment and automated processing

At AstraZeneca, we follow the science to explore and innovate. We are committed to treating, preventing, modifying and even curing some of the world's most complex diseases. We fuse data and technology with the latest scientific innovations to achieve breakthroughs. Our leaders inspire us to make bold decisions and dig deep into the biology of complex diseases. We work seamlessly as one, uniting the best from academia, biotechs and the industry. If you are passionate about science and want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be.

Ready to make a meaningful impact on patients' lives? Apply today to join our dedicated Research & Development team!

For more information about the position please contact hiring manager Constanze Hilgendorf (Constanze.Hilgendorf@astrazeneca.com).

Welcome with your application no later than October 15, 2024.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.