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Senior Scientist - Proteomics/Metabolomics

Location Gaithersburg, Maryland, United States Job ID R-046422 Date posted 03/07/2019

If you’re inspired by the possibilities of science to change lives and you thrive when making brave decisions – join us.

MedImmuneis the worldwide biologics research and development arm of AstraZeneca. Here, you’ll have the opportunity to make a difference in people’s lives every day. As one of the world’s premier biotechnology companies, our mission is centered on delivering life-changing products that advance world health, and help fight and cure disease.  As aSeniorScientist II - Proteomics/MetabolomicsinGaithersburg, MDyou’ll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients’ lives.

We’re constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we’re industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore synergies between small and large molecules.

MedImmune has a dynamic environment that fosters collaboration and innovation. We attract top minds, and we nurture and build top talent.

Main Duties and Responsibilities

You will be an important contributor of the expanding proteomics, metabolomics and protein biochemistry center of excellence using state-of-the-art proteomics technology to investigate a number of biological questions. This is a key proteomics application position that requires comprehensive expertise and hands-on experience in this area. You must be passionate about life science and lab bench work. You must also have a thorough understanding of modern mass spectrometry and chromatography and will lead a small team from the bench. You will support the operation and maintenance of advanced state-of-the-art nanoflow liquid chromatography and mass spectrometry (LC-MS) instrumentation (Orbitrap Fusion, Q-Exactive HF-X, Orbitrap ID-X, Agilent IMS-QTOF, QTRAP6500) that enable cutting-edge proteomic profiling and translational research across our therapeutic areas. 

You have to demonstrate a proven record of being a fast learner, excellent communicator and thoughtful team member.

You should be highly motivated, innovative, detail-oriented, creative, well organized and able to work independently when designing and executing experiments and will be expected to manage and prioritize several different projects and tasks in line with the objectives of the group. Your projects may include development of novel proteomic or metabolomic technologies or application of already existing ones to address current challenges in biology and may entail mass spectrometric analysis of cancer cell lines, tissue samples from animal models and patient material.

Essential Requirements

  • Ph.D. in Proteomics, Metabolomics, Mass Spectrometry, Analytical Chemistry or related field. 
  • 7-10 years of post-doctoral experience in a relevant research area.
  • The candidate should act as a leader from the bench, driving research programs, strategies, and ideas to completion.
  • Possess prior experience in quantitative metabolomics and/or proteomics technology development and/or nano-liquid chromatography and mass spectrometry (LC-MS; ideally on Orbitrap Fusion, Q-Exactive HF-X, Orbitrap ID-X, Agilent IMS-QTOF, and/or QTRAP6500).
  • The candidate should be familiar with the entire metabolomics and/or proteomics pipeline (including sample preparation, LC and MS operation, data analysis) and must be able to conduct independent and creative research.
  • An analytical aptitude for devising innovative scientific or technical solutions is highly desired.
  • Manage multiple collaborative projects between multiple laboratories.
  • Demonstrate scientific productivity and have excellent oral and written communication skills.
  • Drive collaborative efforts cross-functionally and with external stakeholders.
  • Lead a small team of scientists.
  • Demonstrate enthusiasm, motivation, attention to detail and ability to learn new technologies, flexibility and confidence.

Desirable Requirements

  • Ability to collaborate across multiple disciplines to investigate drug candidates and disease properties.
  • Experience with working in a matrix organization.Experience with molecular biology, including cell culture and immunochemistry is highly desired.
  • Experience with writing bioninformatic scripts.
  • Experience with robotic automation.
  • Experience with MaxQuant, Skyline and XC-MS is a plus.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity.  If you know someone who would be a great fit, please share this posting with them.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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