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Senior Scientist - Bioscience Immunology

Location Gaithersburg, Maryland, United States Job ID R-121858 Date posted 25/10/2021

Senior Scientist Bioscience Immunology, Early Respiratory, and Immunology

AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. The vision of AstraZeneca Early Respiratory & Immunology (Early R&I) is centered on delivering life-changing products that advance world health and help fight and cure disease. Early R&I is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. Here, you’ll have the opportunity to make a difference in people’s lives every day.

As a part of the building Immunology Bioscience team within the Early R&I department, we are seeking a highly motivated senior researcher with a strong understanding of adaptive and/or innate immunity and ideally understanding key biological pathways in immune-mediated diseases such as rheumatological and/or gastrointestinal diseases. The role will be based in Gaithersburg within AstraZeneca’s state-of-the-art laboratories where you will follow the science to help drive innovation and advance medicine to help improve patient lives.

In this role, you would be expected to demonstrate an exceptionally high level of enthusiasm for innovative scientific research leading to the discovery and development of novel therapeutics. Ideally, you have expertise in T-, B- and innate immunity and/or pathogenic mechanisms involved in tissue pathology in immune-mediated diseases. Experience in complex co-culture systems and cell imaging, and an ability to apply this experience to an understanding of the basic mechanisms of human immune-mediated disease is preferred.


Main Duties and Responsibilities

In this role, you will be a biology leader in the Bioscience, Immunology team focusing on developing therapeutics for the treatment of Rheumatological and Gastrointestinal Diseases. This job includes a senior lab-based responsibilities and you will have a significant opportunity to drive the direction of the work. The work will be predominantly human in vitro systems, working with primary and disease tissue-derived cells, although knowledge and experience of in vivo science is a bonus. A background in human immunology and immune-mediated diseases and translational approaches to understanding basic biological mechanisms in disease is needed.

  • You will focus your research on characterizing novel immunological pathways in health and disease to aid target validation and drug projects

  • You will contribute and drive strategies for new target identification for the treatment of immune-mediated diseases such as rheumatological and gastrointestinal diseases

  • You will collaborate with scientists from a variety of functional teams in Gaithersburg and with our sites in Cambridge, UK, and Gothenburg, Sweden.

  • You will benefit from daily interaction and collaboration with highly accomplished scientists and the position offers a unique opportunity to work in a dynamic and innovative environment developing your career at the interface of research and drug discovery.

  • You will involve in the development of new assays and Implementing novel technical advances with human tissue cultures

  • Encouragement and support will be provided to help the individual develop specialist knowledge and skillsets.

  • Publication of your work in high-impact journals.

Requirements

  • A Ph.D. in Immunology or a closely related field with postdoctoral experience is required, or a minimum of 7 years relevant experience in the drug development industry, and a good record of publication.

  • Expertise in drug discovery projects in immunology or a closely related field of biology is preferred.

  • Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team to conduct a high-level research project.

  • Excellent experimental technique. Extensive hands-on skills in basic biochemical and molecular techniques including but not limited to cell culture, cell transfection and RNAi techniques, quantification of mRNA (qPCR), Western blot, Immunoprecipitation, and different platforms for measuring proteins (MSD, Luminex).  Expertise in primary human cell culture including co-culture models, expertise in multi-panel FACS, including both intracellular and extracellular cell surface markers are essential, and experience evaluating intracellular trafficking and antibody and complement-mediated effector functions is preferred.  

  • Proven ability to develop, validate and execute biochemical and cell-based assays to investigate novel biological processes.

  • In vivo skills are a strong plus, and experience with experimental models of autoimmunity and inflammation are preferred.

  • Strong written and oral communication skills and the ability to critically analyze data sets

  • Demonstrated ability to run collaborative efforts and utilize external resources to find the most effective solutions to drug discovery problems

  • Experience with mentoring students at the undergraduate and Ph.D. level is preferred.

AstraZeneca has taken critical steps to protecting colleagues, loved ones, and patients from COVID-19 and its variants.  COVID-19 vaccination is required for all US employees, and weekly PCR COVID-19 testing is required for those who are unvaccinated or have an approved accommodation.



AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056710 D SCBO R&D BioPharmaceuticals

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.