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Senior Scientist- ADC Oncology (Hematology)

Location Gaithersburg, Maryland, United States Job ID R-098767 Date posted 25/01/2021

At AstraZeneca, we turn ideas into life changing medicines! Working here means being ambitious, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.

AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers.

Job Description:

We are seeking a highly motivated and independent Senior Scientist with a consistent track record of scientific excellence and project leadership experience in cancer biology to join our antibody-drug conjugates (ADCs) portfolio team within the Early Oncology Discovery group in Gaithersburg, MD! As a Senior Scientist, you will be a key member of a team focused on bringing new ADC projects into the portfolio and advancing them through all stages of pre-clinical development. You will have a direct impact on the drug discovery process, both as a project leader and a hand on contributor in the lab. You will bring your theoretical and practical expertise to lead pipeline projects, establishing program priorities and working with a cross-functional team to deliver pre-clinical datasets to support pipeline progression. You will represent the team in front of governance committees and will present program updates at other internal forums. As part of the team, you will also make intellectual contributions to programs across the ADC Portfolio.

Main Duties and Responsibilities

You will be encouraged to serve as Oncology biology lead for one or more pipeline programs, working collaboratively with cross-functional teams. You will be expected to work in the laboratory, to develop, design, conduct, troubleshoot, and analyze in vitro experiments to assess the function of our ADCs and dissect the mechanism of action of these novel cancer therapeutics.

  • PhD Degree with 2+ years of experience, Master's Degree with 5+ years of experience, or a Bachelor’s degree with 10+ years and project leadership experience in a relevant subject area
  • Proven ability to lead cross functional project teams
  • Prior experience in the biopharmaceutical industry with pre-clinical in vivo models of cancer
  • Experience in pre-clinical models of hematological cancer, and hematological cancer cell biology
  • Solid understanding of cell biology, molecular biology, and/or biochemistry in the context of cancer biology, with a strong desire for continued learning
  • Experience with molecular- and cell-based methodologies such as multicolor flow cytometry, fluorescent and live cell microscopy, cytotoxicity assays, ELISA, qPCR, western blotting, and co-immunoprecipitation
  • Works independently to design and conduct key experiments to support program progression
  • A consistent record of productivity, as demonstrated by scientific publications in high quality peer-reviewed journals
  • Ensures own work, and work of peers, is stays in sync with Good Laboratory Practice, Safety, Health, and Environment standards

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

50056710 D SCBO R&D Oncology (Pascal Soriot (08126850) (Inherited)) (85008610)

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Great culture, great work assignments, supportive management. Rotation opportunity within the company. They value inclusion and diversity.